Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents: The HELENA study

César Agostinis-Sobrinho, Sonia Gómez-Martínez, Esther Nova, Aurora Hernandez, Idoia Labayen, Antonios Kafatos, Frederic Gottand, D. Molnár, Marika Ferrari, Luis A. Moreno, Marcela González-Gross, Nathalie Michels, Azahara Ruperez, Jonatan R. Ruiz, Ascensión Marcos

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the association of lifestyle patterns related to physical activity (PA), sedentariness, and sleep with endocrine, metabolic, and immunological health biomarkers in European adolescents. Methods: The present cross-sectional study comprised 3528 adolescents (1845 girls) (12.5-17.5 years) enrolled in the Healthy Lifestyle in Europe by Nutrition in Adolescence Study. Cluster analysis was performed by including body composition, PA by accelerometry, self-reported sedentary behaviors, and sleep duration. We also measured endocrine, metabolic, and immunological biomarkers. Results: Three-cluster solutions were identified: (a) light-PA time, moderate-vigorous-PA time and sedentary time, (b) light-PA time, moderate-vigorous-PA time, sedentary time and sleep time, (c) light-PA time, moderate-vigorous-PA time, sedentary time and body composition. In addition, each cluster solution was defined as: “healthy,” “medium healthy,” and “unhealthy” according to the presented rating. Analysis of variance showed that overall the healthiest groups from the three clusters analyzed presented a better metabolic profile. A decision tree analysis showed that leptin had a strong association with cluster 3 in both boys and girls, high-density lipoprotein cholesterol had the strongest association with clusters 1 and 3 in boys. Cortisol had the strongest association with cluster 1. HOMA index (homeostatic model assessment) and C3 showed a strong association with cluster 3 in girls. Conclusions: Our results support the existence of different interactions between metabolic health and lifestyle patterns related to PA, sedentariness, and sleep, with some gender-specific findings. These results highlight the importance to consider multiple lifestyle-related health factors in the assessment of adolescents' health to plan favorable strategies.

Original languageEnglish
JournalPediatric Diabetes
DOIs
Publication statusAccepted/In press - Jan 1 2018

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Keywords

  • cardiometabolic biomarkers
  • physical activity
  • sedentary behavior
  • sleep time
  • youth

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

Cite this

Agostinis-Sobrinho, C., Gómez-Martínez, S., Nova, E., Hernandez, A., Labayen, I., Kafatos, A., Gottand, F., Molnár, D., Ferrari, M., Moreno, L. A., González-Gross, M., Michels, N., Ruperez, A., Ruiz, J. R., & Marcos, A. (Accepted/In press). Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents: The HELENA study. Pediatric Diabetes. https://doi.org/10.1111/pedi.12802