LIDOFLAZINE IN THE EARLY STAGES OF ACUTE MYOCARDIAL ISCHAEMIA

SUSAN J. COKER, O. FAGBEMI, J. R. PARRATT

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Pretreatment of anaesthetized rats with intravenously administered lidoflazine (an antianginal agent) reduced the incidence and severity of ventricular arrhythmias which resulted from acute coronary artery ligation. Ventricular fibrillation was completely prevented by doses of 50 μg/kg and 2 mg/kg and no animal so treated died (contrast 50% incidence of fibrillation in the controls and 30% mortality). In anaesthetized greyhound dogs, lidoflazine (2 mg/kg) administration resulted in transient reductions in systemic arterial pressure, LV dP/dt max and cardiac output. Coronary sinus PO2 was markedly increased, indicating pronounced coronary vasodilatation. Lidoflazine pretreatment inhibited the increase in epicardial ST‐segment elevation which resulted, in dogs, from short (3 min) occlusions of the left anterior descending coronary artery. This effect was especially marked at sites where, in control occlusions, ST‐segment elevation was most pronounced. Lidoflazine greatly reduced the number of ventricular ectopic beats which usually resulted from more prolonged (30 min) periods of acute coronary artery occlusion. There was no ventricular fibrillation in these dogs (contrast 25% incidence in the controls). Lidoflazine did not modify the ventricular fibrillation which results from reperfusion of a previously ischaemic area of the left ventricular wall. 1982 British Pharmacological Society

Original languageEnglish
Pages (from-to)347-354
Number of pages8
JournalBritish journal of pharmacology
Volume76
Issue number2
DOIs
Publication statusPublished - Jun 1982

ASJC Scopus subject areas

  • Pharmacology

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