Lichtheimia species exhibit differences in virulence potential

Volker U. Schwartze, Kerstin Hoffmann, Ildikó Nyilasi, T. Papp, C. Vágvölgyi, Sybren de Hoog, Kerstin Voigt, Ilse D. Jacobsen

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Although the number of mucormycosis cases has increased during the last decades, little is known about the pathogenic potential of most mucoralean fungi. Lichtheimia species represent the second and third most common cause of mucormycosis in Europe and worldwide, respectively. To date only three of the five species of the genus have been found to be involved in mucormycosis, namely L. corymbifera, L. ramosa and L. ornata. However, it is not clear whether the clinical situation reflects differences in virulence between the species of Lichtheimia or whether other factors are responsible. In this study the virulence of 46 strains of all five species of Lichtheimia was investigated in chicken embryos. Additionally, strains of the closest-related genus Dichotomocladium were tested. Full virulence was restricted to the clinically relevant species while all strains of L. hyalospora, L. sphaerocystis and Dichotomocladium species were attenuated. Although virulence differences were present in the clinically relevant species, no connection between origin (environmental vs clinical) or phylogenetic position within the species was observed. Physiological studies revealed no clear connection of stress resistance and carbon source utilization with the virulence of the strains. Slower growth at 37°C might explain low virulence of L. hyalospora, L. spaherocystis and Dichotomocladium; however, similarly slow growing strains of L. ornata were fully virulent. Thus, additional factors or a complex interplay of factors determines the virulence of strains. Our data suggest that the clinical situation in fact reflects different virulence potentials in the Lichtheimiaceae.

Original languageEnglish
Article numbere40908
JournalPLoS One
Volume7
Issue number7
DOIs
Publication statusPublished - Jul 20 2012

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Virulence
virulence
Mucormycosis
Virulence Factors
Fungi
Carbon
Sphaerocystis
slow-growing strains
Chickens
stress tolerance
Embryonic Structures
embryo (animal)
pathogenicity
chickens
fungi
Growth
carbon
phylogeny

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Schwartze, V. U., Hoffmann, K., Nyilasi, I., Papp, T., Vágvölgyi, C., de Hoog, S., ... Jacobsen, I. D. (2012). Lichtheimia species exhibit differences in virulence potential. PLoS One, 7(7), [e40908]. https://doi.org/10.1371/journal.pone.0040908

Lichtheimia species exhibit differences in virulence potential. / Schwartze, Volker U.; Hoffmann, Kerstin; Nyilasi, Ildikó; Papp, T.; Vágvölgyi, C.; de Hoog, Sybren; Voigt, Kerstin; Jacobsen, Ilse D.

In: PLoS One, Vol. 7, No. 7, e40908, 20.07.2012.

Research output: Contribution to journalArticle

Schwartze, VU, Hoffmann, K, Nyilasi, I, Papp, T, Vágvölgyi, C, de Hoog, S, Voigt, K & Jacobsen, ID 2012, 'Lichtheimia species exhibit differences in virulence potential', PLoS One, vol. 7, no. 7, e40908. https://doi.org/10.1371/journal.pone.0040908
Schwartze, Volker U. ; Hoffmann, Kerstin ; Nyilasi, Ildikó ; Papp, T. ; Vágvölgyi, C. ; de Hoog, Sybren ; Voigt, Kerstin ; Jacobsen, Ilse D. / Lichtheimia species exhibit differences in virulence potential. In: PLoS One. 2012 ; Vol. 7, No. 7.
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