Hatóanyag liberációja gyógyszeres szuszpenziókból I. Felületaktív anyagok hatása a hatóanyag kioldódására

Translated title of the contribution: Liberation of active substance from pharmaceutical suspensions I. Effect of surfactants on the active substance dissolving

Maher Sourbaji, P. Sípos, Maher Selim, P. Szabó-Révész, I. Erös

Research output: Contribution to journalArticle

Abstract

Liberation of active agent from suspensions containing sulfadimidine was investigated. There are three physico-chemical steps of the process: (i) dissolving active agent in the vehicle of suspension, (ii) partitioning dissolved molecules between the membrane and the suspension, and (iii) diffusion of active substance through membrane into the acceptor phase. The vehicle of suspensions contained surface active agents in 0,01 to 1,00 mass% concentration range. The liberation of active substance was examined with Hanson vertical diffusion cell. A multiplicative function, a square root one and an exponential equation were fitted at the analysis of results. It was established that the square rot function and the exponential one fitted well to the measuring points. Relationships were found between the concentration and HLB values of surfactants and the rate constant of liberation. There is a characteristic correlation between the constants of Higuchi's equation and modified Weibull one, too.

Original languageHungarian
Pages (from-to)142-149
Number of pages8
JournalActa Pharmaceutica Hungarica
Volume77
Issue number2
Publication statusPublished - 2007

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Surface-Active Agents
Suspensions
Pharmaceutical Preparations
Chemical Phenomena
Sulfamethazine
Membranes

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

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title = "Hat{\'o}anyag liber{\'a}ci{\'o}ja gy{\'o}gyszeres szuszpenzi{\'o}kb{\'o}l I. Fel{\"u}letakt{\'i}v anyagok hat{\'a}sa a hat{\'o}anyag kiold{\'o}d{\'a}s{\'a}ra",
abstract = "Liberation of active agent from suspensions containing sulfadimidine was investigated. There are three physico-chemical steps of the process: (i) dissolving active agent in the vehicle of suspension, (ii) partitioning dissolved molecules between the membrane and the suspension, and (iii) diffusion of active substance through membrane into the acceptor phase. The vehicle of suspensions contained surface active agents in 0,01 to 1,00 mass{\%} concentration range. The liberation of active substance was examined with Hanson vertical diffusion cell. A multiplicative function, a square root one and an exponential equation were fitted at the analysis of results. It was established that the square rot function and the exponential one fitted well to the measuring points. Relationships were found between the concentration and HLB values of surfactants and the rate constant of liberation. There is a characteristic correlation between the constants of Higuchi's equation and modified Weibull one, too.",
author = "Maher Sourbaji and P. S{\'i}pos and Maher Selim and P. Szab{\'o}-R{\'e}v{\'e}sz and I. Er{\"o}s",
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T1 - Hatóanyag liberációja gyógyszeres szuszpenziókból I. Felületaktív anyagok hatása a hatóanyag kioldódására

AU - Sourbaji, Maher

AU - Sípos, P.

AU - Selim, Maher

AU - Szabó-Révész, P.

AU - Erös, I.

PY - 2007

Y1 - 2007

N2 - Liberation of active agent from suspensions containing sulfadimidine was investigated. There are three physico-chemical steps of the process: (i) dissolving active agent in the vehicle of suspension, (ii) partitioning dissolved molecules between the membrane and the suspension, and (iii) diffusion of active substance through membrane into the acceptor phase. The vehicle of suspensions contained surface active agents in 0,01 to 1,00 mass% concentration range. The liberation of active substance was examined with Hanson vertical diffusion cell. A multiplicative function, a square root one and an exponential equation were fitted at the analysis of results. It was established that the square rot function and the exponential one fitted well to the measuring points. Relationships were found between the concentration and HLB values of surfactants and the rate constant of liberation. There is a characteristic correlation between the constants of Higuchi's equation and modified Weibull one, too.

AB - Liberation of active agent from suspensions containing sulfadimidine was investigated. There are three physico-chemical steps of the process: (i) dissolving active agent in the vehicle of suspension, (ii) partitioning dissolved molecules between the membrane and the suspension, and (iii) diffusion of active substance through membrane into the acceptor phase. The vehicle of suspensions contained surface active agents in 0,01 to 1,00 mass% concentration range. The liberation of active substance was examined with Hanson vertical diffusion cell. A multiplicative function, a square root one and an exponential equation were fitted at the analysis of results. It was established that the square rot function and the exponential one fitted well to the measuring points. Relationships were found between the concentration and HLB values of surfactants and the rate constant of liberation. There is a characteristic correlation between the constants of Higuchi's equation and modified Weibull one, too.

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