Luteinizing hormone-releasing hormone (LHRH), a hypothalamic neurohormone, forms a complex with Zn ions in solution. In order to explain the structure of this complex, the stability constants of Zn(II) complexes of LHRH and also pyroglutamyl-histidine-methylester, N-acetyl-histamine, and N-acetyl-histidine were established with the use of potentiometric technique. The nuclear magnetic resonance spectroscopy shows that the mode of coordination of Zn(II) to LHRH consists of binding to the imidazole nitrogen and the peptide oxygen of the His-Trp bond.
ASJC Scopus subject areas
- Inorganic Chemistry