LHRH interaction with Zn(II) ions

Wojciech Bal, Henryk Kozlowski, Elzbieta Masiukiewicz, Barbara Rzeszotarska, Imre Sóvágó

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Abstract

Luteinizing hormone-releasing hormone (LHRH), a hypothalamic neurohormone, forms a complex with Zn ions in solution. In order to explain the structure of this complex, the stability constants of Zn(II) complexes of LHRH and also pyroglutamyl-histidine-methylester, N-acetyl-histamine, and N-acetyl-histidine were established with the use of potentiometric technique. The nuclear magnetic resonance spectroscopy shows that the mode of coordination of Zn(II) to LHRH consists of binding to the imidazole nitrogen and the peptide oxygen of the His-Trp bond.

Original languageEnglish
Pages (from-to)135-139
Number of pages5
JournalJournal of Inorganic Biochemistry
Volume37
Issue number2
DOIs
Publication statusPublished - Oct 1989

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ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Bal, W., Kozlowski, H., Masiukiewicz, E., Rzeszotarska, B., & Sóvágó, I. (1989). LHRH interaction with Zn(II) ions. Journal of Inorganic Biochemistry, 37(2), 135-139. https://doi.org/10.1016/0162-0134(89)80036-4