Lewy body variant of Alzheimer's disease: α-synuclein in dystrophic neurites of Aβ plaques

Oliver Wirths, Svenja Weickert, Katalin Majtenyi, Laszlo Havas, Philipp J. Kahle, Masayasu Okochi, Christian Haass, Gerd Multhaup, Konrad Beyreuther, Thomas A. Bayer

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The contribution of α-synuclein accumulation in Alzheimer's disease (AD) plaques is currently a matter of scientific debate. In the present study antisera against the N- and C-terminus, the full-length protein and the central so-called non-amyloid component (NAC) domain of the α-synuclein protein were used to address this question in brains of cases with typical AD and of cases with the Lewy body (LB) variant of AD. In typical AD cases, none of the antisera revealed evidence for coaccumulation of α-synuclein with extracellular Aβ peptides in plaques or in dystrophic neurites decorating the plaque core. Interestingly, cases with mixed pathology of the LB variant of AD revealed accumulation of α-synuclein in LBs and in dystrophic neurites of Aβ plaques. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)3737-3741
Number of pages5
JournalNeuroreport
Volume11
Issue number17
DOIs
Publication statusPublished - Nov 27 2000

    Fingerprint

Keywords

  • Alzheimer's disease
  • Amyloid deposits
  • Familial Alzheimer's disease
  • Immunostaining
  • Lewy body
  • NAC
  • Neuritic plaques
  • Sporadic Alzheimer's disease
  • α-Synuclein

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Wirths, O., Weickert, S., Majtenyi, K., Havas, L., Kahle, P. J., Okochi, M., Haass, C., Multhaup, G., Beyreuther, K., & Bayer, T. A. (2000). Lewy body variant of Alzheimer's disease: α-synuclein in dystrophic neurites of Aβ plaques. Neuroreport, 11(17), 3737-3741. https://doi.org/10.1097/00001756-200011270-00029