Levels of placenta-specific tissue protein 12 (PP12) in serum during normal pregnancy and in patients with trophoblastic tumour

G. Than, I. F. Csaba, D. G. Szabó, Z. J. Bognár, A. Arany, H. Bohn

Research output: Contribution to journalArticle

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Abstract

A sensitive radioimmunoassay method has been developed to measure soluble placental protein 12. Using this method trace amounts of PP12 have also been detected in the sera of healthy non-pregnant subjects (24.0 ± 6.15 μg/l). During normal pregnancy serum PP12 levels rose rapidly reaching a peak value of 139.90 ± 40.26 μg/l at 18 weeks. Serial determinations of PP12 have been made in 31 patients with trophoblastic tumours (16 hydatidiform moles, 10 invasive moles and five choriocarcinomas). It has been found that in patients with hydatidiform and invasive moles its initial values are extremly high (342.9 ± 257.9 μg/l and 279.3 ± 103.1 μg/l, respectively), much exceeding the non-pregnant and normal pregnant values. After evacuation of hydatidiform moles serum-PP12 rapidly fell to the upper limit of normal at 21-28 days, and to normal values at 8-12 weeks after operation. In patients with invasive mole requiring chemotherapy the rate of fall of PP12 level was slower. In patients with choriocarcinoma serum-PP12 levels were moderately raised (59-132 μg/l) and followed the clinical course of the disease. Serum-PP12 levels would seem to be of less value in monitoring patients with trophoblastic tumours than other tumour-markers (hCG, and SP1).

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalArchives of Gynecology
Volume234
Issue number1
DOIs
Publication statusPublished - Nov 1983

Fingerprint

Trophoblastic Neoplasms
Placenta
Invasive Hydatidiform Mole
Pregnancy
Serum
Proteins
Hydatidiform Mole
Choriocarcinoma
Reference Values
Pregnancy Proteins
Physiologic Monitoring
Tumor Biomarkers
Radioimmunoassay
Drug Therapy

Keywords

  • Follow-up investigations
  • Placental protein 12 (PP)
  • PP serum level in normal pregnancy
  • PP serum levels in trophoblastic diseases
  • Radioimmunoassay of PP

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Medicine(all)

Cite this

Levels of placenta-specific tissue protein 12 (PP12) in serum during normal pregnancy and in patients with trophoblastic tumour. / Than, G.; Csaba, I. F.; Szabó, D. G.; Bognár, Z. J.; Arany, A.; Bohn, H.

In: Archives of Gynecology, Vol. 234, No. 1, 11.1983, p. 39-46.

Research output: Contribution to journalArticle

Than, G. ; Csaba, I. F. ; Szabó, D. G. ; Bognár, Z. J. ; Arany, A. ; Bohn, H. / Levels of placenta-specific tissue protein 12 (PP12) in serum during normal pregnancy and in patients with trophoblastic tumour. In: Archives of Gynecology. 1983 ; Vol. 234, No. 1. pp. 39-46.
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