Level of haloperidol in plasma is related to electroencephalographic findings in patients who improve

Pál Czobor, Jan Volavka

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28 Citations (Scopus)


This study analyzed interrelationships among plasma level of haloperidol (HAL), electroencephalographic (EEG) changes, and clinical response in 37 acutely exacerbated schizophrenic patients after a 6-week period of treatment. Two hypotheses were tested: (1) EEG theta response to HAL depends on levels of HAL in plasma, and this relationship is expressed in patients showing a clear clinical response (responders). (2) Responders and nonresponders are characterized by a different neuroleptic EEG profile. EEG examinations (resting, waking EEG) were performed at study entry, end point of the placebo period ("baseline"), and weekly during the entire HAL treatment period. EEG response was measured by power spectral changes in four frequency bands (delta, theta, alpha, and beta); clinical response was assessed by the Brief Psychiatric Rating Scale. There was a significant relationship between HAL plasma levels and EEG theta activity for treatment responders, whereas no relationship was detected for the nonresponders. Furthermore, there were EEG changes (in the delta and alpha bands) that depended on clinical response but did not show any relationship, either in responders or nonresponders, to HAL plasma levels. These results supported both hypotheses.

Original languageEnglish
Pages (from-to)129-144
Number of pages16
JournalPsychiatry research
Issue number2
Publication statusPublished - May 1992



  • Schizophrenia
  • clinical response
  • neuroleptic medication
  • power spectrum

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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