Leukemic ophthalmopathy: A report of 21 pediatric cases

M. L. Curto, P. D'Angelo, F. Lumia, G. Provenzano, A. Zingone, C. Bachelot, S. Bagnulo, H. Behrendt, M. Jankovic, G. Masera, J. Mann, P. Rosito, G. Schaison, D. Schuler

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A multicentric retrospective study on leukemic ophthalmopathy (LO) is reported. It includes 21 patients, 16 males and 5 females, with acute leukemia (AL) observed in 10 SIOP centers. LO developed in three patients at the time of diagnosis of AL; five patients were in first complete remission (three off therapy); four patients were in second or third remission; and nine were in combined relapse. Most frequent symptoms were blurred vision, photophobia, and ocular pain. Two patients with acute nonlymphoblastic leukemia died before treatment; another underwent bone marrow transplantation; one patient with B-cell acute lymphoblastic leukemia (B- ALL) treated with chemotherapy and radiotherapy died 4 months after LO the remaining 17 children were treated according to different schedules with (10) or without (7) radiotherapy on the affected eye. Twelve patients achieved ocular remission and four of these had a second ocular relapse. Complete remission after LO treatment lasting for more than 3, 7, 24, 29 months was observed in four patients. The authors conclude that cure is possible in patients who had LO in first complete remission treated with chemotherapy and radiotherapy at high dose on the affected eye.

Original languageEnglish
Pages (from-to)8-13
Number of pages6
JournalMedical and Pediatric Oncology
Volume23
Issue number1
DOIs
Publication statusPublished - 1994

Fingerprint

Pediatrics
Radiotherapy
Leukemia
Eye Pain
Recurrence
Drug Therapy
Photophobia
Bone Marrow Transplantation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Appointments and Schedules
B-Lymphocytes
Therapeutics
Retrospective Studies

Keywords

  • acute leukemia
  • relapse
  • remission

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Cite this

Curto, M. L., D'Angelo, P., Lumia, F., Provenzano, G., Zingone, A., Bachelot, C., ... Schuler, D. (1994). Leukemic ophthalmopathy: A report of 21 pediatric cases. Medical and Pediatric Oncology, 23(1), 8-13. https://doi.org/10.1002/mpo.2950230103

Leukemic ophthalmopathy : A report of 21 pediatric cases. / Curto, M. L.; D'Angelo, P.; Lumia, F.; Provenzano, G.; Zingone, A.; Bachelot, C.; Bagnulo, S.; Behrendt, H.; Jankovic, M.; Masera, G.; Mann, J.; Rosito, P.; Schaison, G.; Schuler, D.

In: Medical and Pediatric Oncology, Vol. 23, No. 1, 1994, p. 8-13.

Research output: Contribution to journalArticle

Curto, ML, D'Angelo, P, Lumia, F, Provenzano, G, Zingone, A, Bachelot, C, Bagnulo, S, Behrendt, H, Jankovic, M, Masera, G, Mann, J, Rosito, P, Schaison, G & Schuler, D 1994, 'Leukemic ophthalmopathy: A report of 21 pediatric cases', Medical and Pediatric Oncology, vol. 23, no. 1, pp. 8-13. https://doi.org/10.1002/mpo.2950230103
Curto ML, D'Angelo P, Lumia F, Provenzano G, Zingone A, Bachelot C et al. Leukemic ophthalmopathy: A report of 21 pediatric cases. Medical and Pediatric Oncology. 1994;23(1):8-13. https://doi.org/10.1002/mpo.2950230103
Curto, M. L. ; D'Angelo, P. ; Lumia, F. ; Provenzano, G. ; Zingone, A. ; Bachelot, C. ; Bagnulo, S. ; Behrendt, H. ; Jankovic, M. ; Masera, G. ; Mann, J. ; Rosito, P. ; Schaison, G. ; Schuler, D. / Leukemic ophthalmopathy : A report of 21 pediatric cases. In: Medical and Pediatric Oncology. 1994 ; Vol. 23, No. 1. pp. 8-13.
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