Szövodmények és társult megbetegedések rheumatoid arthritisben - 234 elhunyt beteg patológiai és klinikai adatainak retrospektív elemzése

Translated title of the contribution: Lethal complications and associated diseases of rheumatoid arthritis - A retrospective clinicopathologic study of 234 autopsy patients

M. Bély, Ágnes Apáthy

Research output: Contribution to journalArticle

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Abstract

Objective: Complications and/or associated diseases in rheumatoid arthritis can present atypical clinical manifestations which may lead to an incorrect or delayed diagnosis. The aim of this study was to determine: (1) the complications of rheumatoid arthritis, the accompanying diseases, and the mortality of these, (2) the clinically missed diagnoses of complications and/or associated diseases, (3) the possible links between coexistent complications of rheumatoid arthritis and/or diseases associated with it, furthermore the possible role of these in the mortality of rheumatoid arthritis patients. Methods: Between 1970 and 1999 10,860 patients died at the National Institute of Rheumatology, and among them 234 with rheumatoid arthritis (diagnosed clinically according to the criteria of the American College of Rheumatology). The associated and basic disease, complication (s), and causes of death were determined on the basis of clinical records and in each case the autopsy findings were confirmed by a review of extensive histological material (50-100 tissue blocks from each patient). Results: The complications of rheumatoid arthritis led to death in 152 (65%) of 234 patients. The complications of RA were clinically recognized in 109 (46.6%, 71.7 rel%) and missed in 43 (18.4% 28.3 rel%) of 152 patients. More than two thirds of lethal complications related to rheumatoid arthritis were diagnosed clinically. The remaining 82 (35%) of 234 rheumatoid arthritis patients died of associated diseases; the cause of death was clinically recognized in 78 (33.3%, 95.1 rel%) of 82 cases. There was a significant and positive correlation (1) between vasculitis and cardiac insufficiency (X2 = 6.37, p 2 = 4.18, p 2 = 3.86, p 2= 54.84, p 2 = 97.04, p 2 = 5.10, p 2= 14.58, p 2 = 3.81, p 2 = 9.31, p 2 = 6.82, p 2 = 3.81, p 2= 12.06, p 2 = 13.22, p2= 10.82, p 2 = 4.18, p

Original languageHungarian
Pages (from-to)1063-1076
Number of pages14
JournalOrvosi Hetilap
Volume147
Issue number23
Publication statusPublished - Jun 11 2006

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Autopsy
Rheumatoid Arthritis
Retrospective Studies
Cause of Death
Mortality
Delayed Diagnosis
Rheumatology
Vasculitis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Szövodmények és társult megbetegedések rheumatoid arthritisben - 234 elhunyt beteg patológiai és klinikai adatainak retrospektív elemzése. / Bély, M.; Apáthy, Ágnes.

In: Orvosi Hetilap, Vol. 147, No. 23, 11.06.2006, p. 1063-1076.

Research output: Contribution to journalArticle

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title = "Sz{\"o}vodm{\'e}nyek {\'e}s t{\'a}rsult megbeteged{\'e}sek rheumatoid arthritisben - 234 elhunyt beteg patol{\'o}giai {\'e}s klinikai adatainak retrospekt{\'i}v elemz{\'e}se",
abstract = "Objective: Complications and/or associated diseases in rheumatoid arthritis can present atypical clinical manifestations which may lead to an incorrect or delayed diagnosis. The aim of this study was to determine: (1) the complications of rheumatoid arthritis, the accompanying diseases, and the mortality of these, (2) the clinically missed diagnoses of complications and/or associated diseases, (3) the possible links between coexistent complications of rheumatoid arthritis and/or diseases associated with it, furthermore the possible role of these in the mortality of rheumatoid arthritis patients. Methods: Between 1970 and 1999 10,860 patients died at the National Institute of Rheumatology, and among them 234 with rheumatoid arthritis (diagnosed clinically according to the criteria of the American College of Rheumatology). The associated and basic disease, complication (s), and causes of death were determined on the basis of clinical records and in each case the autopsy findings were confirmed by a review of extensive histological material (50-100 tissue blocks from each patient). Results: The complications of rheumatoid arthritis led to death in 152 (65{\%}) of 234 patients. The complications of RA were clinically recognized in 109 (46.6{\%}, 71.7 rel{\%}) and missed in 43 (18.4{\%} 28.3 rel{\%}) of 152 patients. More than two thirds of lethal complications related to rheumatoid arthritis were diagnosed clinically. The remaining 82 (35{\%}) of 234 rheumatoid arthritis patients died of associated diseases; the cause of death was clinically recognized in 78 (33.3{\%}, 95.1 rel{\%}) of 82 cases. There was a significant and positive correlation (1) between vasculitis and cardiac insufficiency (X2 = 6.37, p 2 = 4.18, p 2 = 3.86, p 2= 54.84, p 2 = 97.04, p 2 = 5.10, p 2= 14.58, p 2 = 3.81, p 2 = 9.31, p 2 = 6.82, p 2 = 3.81, p 2= 12.06, p 2 = 13.22, p2= 10.82, p 2 = 4.18, p",
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AU - Apáthy, Ágnes

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N2 - Objective: Complications and/or associated diseases in rheumatoid arthritis can present atypical clinical manifestations which may lead to an incorrect or delayed diagnosis. The aim of this study was to determine: (1) the complications of rheumatoid arthritis, the accompanying diseases, and the mortality of these, (2) the clinically missed diagnoses of complications and/or associated diseases, (3) the possible links between coexistent complications of rheumatoid arthritis and/or diseases associated with it, furthermore the possible role of these in the mortality of rheumatoid arthritis patients. Methods: Between 1970 and 1999 10,860 patients died at the National Institute of Rheumatology, and among them 234 with rheumatoid arthritis (diagnosed clinically according to the criteria of the American College of Rheumatology). The associated and basic disease, complication (s), and causes of death were determined on the basis of clinical records and in each case the autopsy findings were confirmed by a review of extensive histological material (50-100 tissue blocks from each patient). Results: The complications of rheumatoid arthritis led to death in 152 (65%) of 234 patients. The complications of RA were clinically recognized in 109 (46.6%, 71.7 rel%) and missed in 43 (18.4% 28.3 rel%) of 152 patients. More than two thirds of lethal complications related to rheumatoid arthritis were diagnosed clinically. The remaining 82 (35%) of 234 rheumatoid arthritis patients died of associated diseases; the cause of death was clinically recognized in 78 (33.3%, 95.1 rel%) of 82 cases. There was a significant and positive correlation (1) between vasculitis and cardiac insufficiency (X2 = 6.37, p 2 = 4.18, p 2 = 3.86, p 2= 54.84, p 2 = 97.04, p 2 = 5.10, p 2= 14.58, p 2 = 3.81, p 2 = 9.31, p 2 = 6.82, p 2 = 3.81, p 2= 12.06, p 2 = 13.22, p2= 10.82, p 2 = 4.18, p

AB - Objective: Complications and/or associated diseases in rheumatoid arthritis can present atypical clinical manifestations which may lead to an incorrect or delayed diagnosis. The aim of this study was to determine: (1) the complications of rheumatoid arthritis, the accompanying diseases, and the mortality of these, (2) the clinically missed diagnoses of complications and/or associated diseases, (3) the possible links between coexistent complications of rheumatoid arthritis and/or diseases associated with it, furthermore the possible role of these in the mortality of rheumatoid arthritis patients. Methods: Between 1970 and 1999 10,860 patients died at the National Institute of Rheumatology, and among them 234 with rheumatoid arthritis (diagnosed clinically according to the criteria of the American College of Rheumatology). The associated and basic disease, complication (s), and causes of death were determined on the basis of clinical records and in each case the autopsy findings were confirmed by a review of extensive histological material (50-100 tissue blocks from each patient). Results: The complications of rheumatoid arthritis led to death in 152 (65%) of 234 patients. The complications of RA were clinically recognized in 109 (46.6%, 71.7 rel%) and missed in 43 (18.4% 28.3 rel%) of 152 patients. More than two thirds of lethal complications related to rheumatoid arthritis were diagnosed clinically. The remaining 82 (35%) of 234 rheumatoid arthritis patients died of associated diseases; the cause of death was clinically recognized in 78 (33.3%, 95.1 rel%) of 82 cases. There was a significant and positive correlation (1) between vasculitis and cardiac insufficiency (X2 = 6.37, p 2 = 4.18, p 2 = 3.86, p 2= 54.84, p 2 = 97.04, p 2 = 5.10, p 2= 14.58, p 2 = 3.81, p 2 = 9.31, p 2 = 6.82, p 2 = 3.81, p 2= 12.06, p 2 = 13.22, p2= 10.82, p 2 = 4.18, p

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KW - Autopsy study

KW - Cause of death

KW - Clinicopathology

KW - Complications

KW - Rheumatoid arthritis

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