Lessons learned from Myc/Max/Mad knockout mice

M. Pirity, J. K. Blanck, N. Schreiber-Agus

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The past two decades of gene targeting experiments have allowed us to make significant strides towards understanding how the Myc/Max/Mad network influences multiple aspects of cellular behavior during development. Here we summarize the findings obtained from the myc/max/mad knockout mice generated to date, namely those in which the N-myc, c-myc, L-myc, mad1, mxi1, mad3, mnt, or max genes have been targeted. A compilation of lessons we have learned from these myc/max/mad knockout mouse models, and suggestions as to where future efforts could be focused, are also presented.

Original languageEnglish
Pages (from-to)205-234
Number of pages30
JournalCurrent Topics in Microbiology and Immunology
Volume302
DOIs
Publication statusPublished - 2006

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Knockout Mice
Gene Targeting
Genes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology and Microbiology(all)
  • Microbiology

Cite this

Lessons learned from Myc/Max/Mad knockout mice. / Pirity, M.; Blanck, J. K.; Schreiber-Agus, N.

In: Current Topics in Microbiology and Immunology, Vol. 302, 2006, p. 205-234.

Research output: Contribution to journalArticle

Pirity, M. ; Blanck, J. K. ; Schreiber-Agus, N. / Lessons learned from Myc/Max/Mad knockout mice. In: Current Topics in Microbiology and Immunology. 2006 ; Vol. 302. pp. 205-234.
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