From the evaluated ONTARGET, ALTITUDE, ACCOMPLISH, ROADMAP, and ACCORD-BP studies a conclusion can be drawn that though microalbuminuria/proteinuria is a strong epidemiological biomarker, in interventional studies it is not necessarily a reliable surrogate endpoint as actual renal function may change in an opposite way. Namely, some therapeutic measures improving microalbuminuria/proteinuria may actually worsen renal function. In case of procedures such as blood pressure lowering or measure of RAS blockade an optimum point on a J-curve may exist. Orv. Hetil., 2013, 154, 243-247.
|Translated title of the contribution||Lessons from the novel renoprotective studies made by antihypertensive drugs|
|Number of pages||5|
|Publication status||Published - Feb 18 2013|
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