A leptin és glukóz metabolizmus evészavarokban.

Translated title of the contribution: Leptin and glucose metabolism in eating disorders.

Agnes Gáti, Bea Pászthy, I. Wittmann, Ildikó Abrahám, Sára Jeges, Ferenc Túry

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

AIM: Leptin, which was discovered only a decade ago, is a peptide that informs hypothalamic areas about the energy balance of the body. New research findings, has suggested a possible role of leptin in eating disorders as well. Few data are available about the relationship between leptin, insulin and glucose metabolism in the pathomechanism of eating disorders. The authors were searching for answers to these relationships in their investigations. METHODS: The study groups included 56 patients with eating disorders and 22 healthy subjects served as controls. The diagnosis was based on DSM-IV criteria. For measuring leptin, insulin and C-peptide serum concentrations a radioimmunoassay method was applied, and serum glucose concentrations were detected by spectrofluorimetry. Detailed statistical analysis of the results was carried out. RESULTS: A correlation between BMI and serum leptin concentration could be proved only in anorectic patients. In contrast to former findings, there was no correlation between BMI and leptin concentration in the bulimia group, and the leptin concentrations were significantly higher in bulimic patients than in the control group. During the glucose tolerance test, leptin levels showed a significant decrease in the anorexia group. CONCLUSION: The results raise the possibility of a direct effect of central regulatory mechanisms of food intake in the pathomechanism of anorexia nervosa.

Original languageHungarian
Pages (from-to)163-169
Number of pages7
JournalPsychiatria Hungarica : A Magyar Pszichiátriai Társaság tudományos folyóirata
Volume22
Issue number2
Publication statusPublished - 2007

Fingerprint

Leptin
Glucose
Serum
Insulin
Appetite Depressants
Bulimia
Feeding and Eating Disorders
C-Peptide
Anorexia Nervosa
Anorexia
Glucose Tolerance Test
Diagnostic and Statistical Manual of Mental Disorders
Radioimmunoassay
Healthy Volunteers
Eating
Control Groups
Peptides
Research

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

A leptin és glukóz metabolizmus evészavarokban. / Gáti, Agnes; Pászthy, Bea; Wittmann, I.; Abrahám, Ildikó; Jeges, Sára; Túry, Ferenc.

In: Psychiatria Hungarica : A Magyar Pszichiátriai Társaság tudományos folyóirata, Vol. 22, No. 2, 2007, p. 163-169.

Research output: Contribution to journalArticle

Gáti, Agnes ; Pászthy, Bea ; Wittmann, I. ; Abrahám, Ildikó ; Jeges, Sára ; Túry, Ferenc. / A leptin és glukóz metabolizmus evészavarokban. In: Psychiatria Hungarica : A Magyar Pszichiátriai Társaság tudományos folyóirata. 2007 ; Vol. 22, No. 2. pp. 163-169.
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