Left ventricular twist is impaired in acromegaly

Insights from the three-dimensional speckle tracking echocardiographic MAGYAR-Path Study

Árpád Kormányos, Péter Domsik, Anita Kalapos, Andrea Orosz, C. Lengyel, Zsuzsanna Valkusz, Attila Trencsányi, T. Forster, Attila Nemes

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: Acromegaly is a rare, chronic, disfiguring, and debilitating disease caused, in 90% of cases, by a benign monoclonal growth hormone–secreting pituitary adenoma. The present study aimed to assess left ventricular (LV) rotational and twist mechanics in acromegalic patients and to compare their results to age- and gender-matched healthy controls. Methods: The present study comprised 24 acromegalic patients, from which 4 were excluded due to insufficient image quality (mean age: 57.8 ± 13.7 years, 7 men). The control group consisted of 18 age- and gender-matched healthy individuals (mean age: 54.8 ± 6.9 years, 8 men). Results: In 4 out of 20 acromegalic patients, LV showed near absence of twist, as the so-called LV “rigid body rotation” (RBR). Between all acromegalic patients without LV-RBR and controls, both LV basal (–3.76 ± 1.73 vs. −6.17 ± 2.66°, P =.004) and apical rotation (6.12 ± 4.03 vs. 10.81 ± 3.65°, P =.001) and LV twist (9.88 ± 4.74 vs. 16.98 ± 3.88°, P <.001) differed significantly. Between active and nonactive acromegaly subgroups, only the time-to-peak LV twist (377 ± 78 vs. 229 ± 97 ms, P =.005) showed significant difference. Conclusions: Acromegaly is associated with impaired LV rotation and twist as assessed by 3-dimensional speckle tracking echocardiography. LV-RBR is a frequent phenomenon in acromegaly.

Original languageEnglish
Pages (from-to)122-128
Number of pages7
JournalJournal of Clinical Ultrasound
Volume46
Issue number2
DOIs
Publication statusPublished - Feb 1 2018

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Acromegaly
Pituitary Neoplasms
Mechanics
Echocardiography
Control Groups
Growth

Keywords

  • 3-dimensional
  • acromegaly
  • echocardiography
  • left ventricular rotation
  • twist

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Left ventricular twist is impaired in acromegaly : Insights from the three-dimensional speckle tracking echocardiographic MAGYAR-Path Study. / Kormányos, Árpád; Domsik, Péter; Kalapos, Anita; Orosz, Andrea; Lengyel, C.; Valkusz, Zsuzsanna; Trencsányi, Attila; Forster, T.; Nemes, Attila.

In: Journal of Clinical Ultrasound, Vol. 46, No. 2, 01.02.2018, p. 122-128.

Research output: Contribution to journalArticle

Kormányos, Árpád ; Domsik, Péter ; Kalapos, Anita ; Orosz, Andrea ; Lengyel, C. ; Valkusz, Zsuzsanna ; Trencsányi, Attila ; Forster, T. ; Nemes, Attila. / Left ventricular twist is impaired in acromegaly : Insights from the three-dimensional speckle tracking echocardiographic MAGYAR-Path Study. In: Journal of Clinical Ultrasound. 2018 ; Vol. 46, No. 2. pp. 122-128.
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AU - Kormányos, Árpád

AU - Domsik, Péter

AU - Kalapos, Anita

AU - Orosz, Andrea

AU - Lengyel, C.

AU - Valkusz, Zsuzsanna

AU - Trencsányi, Attila

AU - Forster, T.

AU - Nemes, Attila

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Y1 - 2018/2/1

N2 - Introduction: Acromegaly is a rare, chronic, disfiguring, and debilitating disease caused, in 90% of cases, by a benign monoclonal growth hormone–secreting pituitary adenoma. The present study aimed to assess left ventricular (LV) rotational and twist mechanics in acromegalic patients and to compare their results to age- and gender-matched healthy controls. Methods: The present study comprised 24 acromegalic patients, from which 4 were excluded due to insufficient image quality (mean age: 57.8 ± 13.7 years, 7 men). The control group consisted of 18 age- and gender-matched healthy individuals (mean age: 54.8 ± 6.9 years, 8 men). Results: In 4 out of 20 acromegalic patients, LV showed near absence of twist, as the so-called LV “rigid body rotation” (RBR). Between all acromegalic patients without LV-RBR and controls, both LV basal (–3.76 ± 1.73 vs. −6.17 ± 2.66°, P =.004) and apical rotation (6.12 ± 4.03 vs. 10.81 ± 3.65°, P =.001) and LV twist (9.88 ± 4.74 vs. 16.98 ± 3.88°, P <.001) differed significantly. Between active and nonactive acromegaly subgroups, only the time-to-peak LV twist (377 ± 78 vs. 229 ± 97 ms, P =.005) showed significant difference. Conclusions: Acromegaly is associated with impaired LV rotation and twist as assessed by 3-dimensional speckle tracking echocardiography. LV-RBR is a frequent phenomenon in acromegaly.

AB - Introduction: Acromegaly is a rare, chronic, disfiguring, and debilitating disease caused, in 90% of cases, by a benign monoclonal growth hormone–secreting pituitary adenoma. The present study aimed to assess left ventricular (LV) rotational and twist mechanics in acromegalic patients and to compare their results to age- and gender-matched healthy controls. Methods: The present study comprised 24 acromegalic patients, from which 4 were excluded due to insufficient image quality (mean age: 57.8 ± 13.7 years, 7 men). The control group consisted of 18 age- and gender-matched healthy individuals (mean age: 54.8 ± 6.9 years, 8 men). Results: In 4 out of 20 acromegalic patients, LV showed near absence of twist, as the so-called LV “rigid body rotation” (RBR). Between all acromegalic patients without LV-RBR and controls, both LV basal (–3.76 ± 1.73 vs. −6.17 ± 2.66°, P =.004) and apical rotation (6.12 ± 4.03 vs. 10.81 ± 3.65°, P =.001) and LV twist (9.88 ± 4.74 vs. 16.98 ± 3.88°, P <.001) differed significantly. Between active and nonactive acromegaly subgroups, only the time-to-peak LV twist (377 ± 78 vs. 229 ± 97 ms, P =.005) showed significant difference. Conclusions: Acromegaly is associated with impaired LV rotation and twist as assessed by 3-dimensional speckle tracking echocardiography. LV-RBR is a frequent phenomenon in acromegaly.

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