Disfunção da aurícula esquerda na amiloidose cardíaca de cadeias leves e na miocardiopatia hipertrófica – Uma análise comparativa por ecocardiograma tridimensional com speckle tracking do estudo MAGYAR-Path

Translated title of the contribution: Left atrial dysfunction in light-chain cardiac amyloidosis and hypertrophic cardiomyopathy – A comparative three-dimensional speckle-tracking echocardiographic analysis from the MAGYAR-Path Study

Dóra Földeák, Árpád Kormányos, Péter Domsik, Anita Kalapos, Györgyike Piros, Nóra Ambrus, Zénó Ajtay, Róbert Sepp, Zita Borbényi, Tamás Forster, Attila Nemes

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction: While cardiac amyloidosis (CA) is a rare systemic disease characterized by extracellular deposition of protein-derived fibrils, hypertrophic cardiomyopathy (HCM) is histopathologically characterized by myocyte hypertrophy and disarray, interstitial fibrosis, and small intramural coronary arteriole dysplasia. The aim of the present study was to compare left atrial (LA) volumetric and functional characteristics between light-chain (AL) CA and HCM by three-dimensional (3D) speckle-tracking echocardiography (STE). Methods: The AL-CA group initially consisted of 17 patients with AL-CA, but one patient was excluded due to inadequate image quality, and so the study population consisted of 16 patients (mean age: 64.0±9.6 years, five men). Their results were compared with data on 20 age-matched HCM patients (mean age: 59.8±5.2 years, 10 men) and on 16 age-matched healthy controls (mean age: 58.2±7.2 years, six men). Complete two-dimensional Doppler echocardiography and 3D-STE were performed in all cases. Results: Significantly increased LA volumes were observed in both AL-CA and HCM compared with the control group. Only active atrial emptying fraction was found to be significantly reduced in AL-CA patients compared to controls. Peak global and mean segmental circumferential, longitudinal and area strains showed significant reductions in AL-CA patients compared with controls, but only peak mean segmental longitudinal strain differed significantly between HCM patients and controls. While no differences were demonstrated in global and mean segmental strain at atrial contraction between HCM patients and controls, AL-CA patients showed reductions in certain strain parameters compared to controls and HCM patients. Conclusions: Different patterns of LA functional characteristics were demonstrated in AL-CA and HCM patients by 3D-STE.

Original languagePortuguese
Pages (from-to)905-913
Number of pages9
JournalRevista Portuguesa de Cardiologia
Volume36
Issue number12
DOIs
Publication statusPublished - Dec 1 2017

Fingerprint

Hypertrophic Cardiomyopathy
Amyloidosis
Light
Echocardiography
Doppler Echocardiography
Arterioles
Rare Diseases
Muscle Cells
Hypertrophy
Fibrosis

Keywords

  • Cardiac amyloidosis
  • Echocardiography
  • Function
  • Hypertrophic cardiomyopathy
  • Left atrium
  • Speckle-tracking
  • Three-dimensional

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Disfunção da aurícula esquerda na amiloidose cardíaca de cadeias leves e na miocardiopatia hipertrófica – Uma análise comparativa por ecocardiograma tridimensional com speckle tracking do estudo MAGYAR-Path. / Földeák, Dóra; Kormányos, Árpád; Domsik, Péter; Kalapos, Anita; Piros, Györgyike; Ambrus, Nóra; Ajtay, Zénó; Sepp, Róbert; Borbényi, Zita; Forster, Tamás; Nemes, Attila.

In: Revista Portuguesa de Cardiologia, Vol. 36, No. 12, 01.12.2017, p. 905-913.

Research output: Contribution to journalArticle

Földeák, Dóra ; Kormányos, Árpád ; Domsik, Péter ; Kalapos, Anita ; Piros, Györgyike ; Ambrus, Nóra ; Ajtay, Zénó ; Sepp, Róbert ; Borbényi, Zita ; Forster, Tamás ; Nemes, Attila. / Disfunção da aurícula esquerda na amiloidose cardíaca de cadeias leves e na miocardiopatia hipertrófica – Uma análise comparativa por ecocardiograma tridimensional com speckle tracking do estudo MAGYAR-Path. In: Revista Portuguesa de Cardiologia. 2017 ; Vol. 36, No. 12. pp. 905-913.
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abstract = "Introduction: While cardiac amyloidosis (CA) is a rare systemic disease characterized by extracellular deposition of protein-derived fibrils, hypertrophic cardiomyopathy (HCM) is histopathologically characterized by myocyte hypertrophy and disarray, interstitial fibrosis, and small intramural coronary arteriole dysplasia. The aim of the present study was to compare left atrial (LA) volumetric and functional characteristics between light-chain (AL) CA and HCM by three-dimensional (3D) speckle-tracking echocardiography (STE). Methods: The AL-CA group initially consisted of 17 patients with AL-CA, but one patient was excluded due to inadequate image quality, and so the study population consisted of 16 patients (mean age: 64.0±9.6 years, five men). Their results were compared with data on 20 age-matched HCM patients (mean age: 59.8±5.2 years, 10 men) and on 16 age-matched healthy controls (mean age: 58.2±7.2 years, six men). Complete two-dimensional Doppler echocardiography and 3D-STE were performed in all cases. Results: Significantly increased LA volumes were observed in both AL-CA and HCM compared with the control group. Only active atrial emptying fraction was found to be significantly reduced in AL-CA patients compared to controls. Peak global and mean segmental circumferential, longitudinal and area strains showed significant reductions in AL-CA patients compared with controls, but only peak mean segmental longitudinal strain differed significantly between HCM patients and controls. While no differences were demonstrated in global and mean segmental strain at atrial contraction between HCM patients and controls, AL-CA patients showed reductions in certain strain parameters compared to controls and HCM patients. Conclusions: Different patterns of LA functional characteristics were demonstrated in AL-CA and HCM patients by 3D-STE.",
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AU - Földeák, Dóra

AU - Kormányos, Árpád

AU - Domsik, Péter

AU - Kalapos, Anita

AU - Piros, Györgyike

AU - Ambrus, Nóra

AU - Ajtay, Zénó

AU - Sepp, Róbert

AU - Borbényi, Zita

AU - Forster, Tamás

AU - Nemes, Attila

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KW - Speckle-tracking

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