Lectin-binding pattern in human non-Hodgkin lymphoma xenografts

L. Kopper, J. Timar, A. Bankfalvi

Research output: Contribution to journalArticle

Abstract

The glycan profile of cell surface proteins has been studied on three human non-Hodgkin lymphoma xenografts of B-cell origin using a panel of biotinylated lectins. All three lines showed a more heterogeneous lectin-binding pattern than normal peripheral blood lymphocytes (PBLs) involving both the inner core and antenna part of the glycans. The conservative inner core (N-N-acetylchitobiose and oligomannose) was similar but fucosylated to various extents in the different lymphomas. The structure of the antennae of PBLs was characterized by glcNac-gal and gal/Nac-gal-Sa sequences, while in lymphomas additional asialo as well as sialylated gal/Nac containing antennae have been identified. This study suggests that NHLs sharing many immunophenotypic features show intertumoral differences in their lectin-binding pattern.

Original languageEnglish
Pages (from-to)1429-1433
Number of pages5
JournalAnticancer research
Volume8
Issue number6
Publication statusPublished - Dec 1 1988

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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