Lead(II) complexes of oligopeptides containing two cysteine residues

Györgyi Szunyog, K. Várnagy

Research output: Contribution to journalArticle

Abstract

The complex formation processes of three oligopeptides (CysSerSerAlaCysSer-NH2, CSSACS-NH2; AlaCysSerSerAlaCysSer-NH2, ACSSACS-NH2; SerSerCysSerSerAlaCysSer-NH2, SSCSSACS-NH2) were studied in the presence of toxic lead(II) ions and compared to those of toxic cadmium(II) and essential zinc(II) ions. The stoichiometry and stability constants of the metal complexes were determined by potentiometry, while their structures were supported by means of UV- and NMR-spectroscopy. For hexapeptide containing cysteine in N-terminal position the (NH2,S) donor groups are the primary metal binding site forming 5-membered chelate ring, and the coordination of C-terminal thiolate group contributes the stability of mono(ligand) complex excluding the formation of bis(ligand) species. The (S,S) donor set is, however, the main binding site, if the –CSSAC– sequence is farther from N-terminal amino group in the molecules, and mono- and bis(ligand) complexes are formed. The metal binding affinity of all three ligands are higher for lead(II) ion than zinc(II) ion resulting good selectivity of ligands for lead(II) over zinc(II).

Original languageEnglish
Pages (from-to)157-164
Number of pages8
JournalInorganica Chimica Acta
Volume472
DOIs
Publication statusPublished - Mar 1 2018

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Oligopeptides
cysteine
Cysteine
Lead
Ligands
ligands
Ions
Zinc
zinc
Poisons
Binding sites
ions
Metals
Binding Sites
metals
potentiometric analysis
Coordination Complexes
Metal complexes
Ultraviolet spectroscopy
Cadmium

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

Lead(II) complexes of oligopeptides containing two cysteine residues. / Szunyog, Györgyi; Várnagy, K.

In: Inorganica Chimica Acta, Vol. 472, 01.03.2018, p. 157-164.

Research output: Contribution to journalArticle

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