Lead ions close steady-state sodium channels in Helix neurons

O. N. Osipenko, J. Györi, T. Kiss

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Extracellularly applied Pb2+ (1-150 μM) induced an outward current (IPb) in intracellularly perfused snail neurons. The current-voltage relationship of the Pb2+-induced current was linear over the potential range of -100 to -40 mV with negative slope conductance. The Pb-induced current was strongly dependent on the Na+ gradient. The IPb in intra- or extracellular K+- and Cl--free or -rich solutions was almost the same as in control external and internal salines. The negative slope of the I-V curve and the decreased conductivity during Pb2+ application suggested that IPb is owing to the blocking of the resting Na conductance. Data obtained from single-channel measurements also supported this conclusion. Patch-clamp data showed that the steady-state Na channel has a conductance of 14pS and both closed and open time-distributions displayed single exponential character.

Original languageEnglish
Pages (from-to)483-489
Number of pages7
JournalNeuroscience
Volume50
Issue number2
DOIs
Publication statusPublished - 1992

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Internal-External Control
Sodium Channels
Snails
Ions
Neurons
Lead

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lead ions close steady-state sodium channels in Helix neurons. / Osipenko, O. N.; Györi, J.; Kiss, T.

In: Neuroscience, Vol. 50, No. 2, 1992, p. 483-489.

Research output: Contribution to journalArticle

Osipenko, O. N. ; Györi, J. ; Kiss, T. / Lead ions close steady-state sodium channels in Helix neurons. In: Neuroscience. 1992 ; Vol. 50, No. 2. pp. 483-489.
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