LCT 13910 C/T polymorphism, serum calcium, and bone mineral density in postmenopausal women

K. Bácsi, J. Kósa, Á Lazáry, B. Balla, H. Horváth, A. Kis, Z. Nagy, I. Takács, P. Lakatos, G. Speer

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Summary: LCT 13910 CC genotype is associated with lactose intolerance, a condition often resulting in reduced milk intake. Women with the CC genotype were found to have decreased serum calcium and reduced bone mineral density. Introduction: The CC genotype of the 13910 C/T polymorphism of the LCT gene is linked to lactose intolerance and low calcium intake. Methods: We studied 595 postmenopausal women, including 267 osteoporotic, 200 osteopenic, and 128 healthy subjects. Genotyping, osteodensitometry, and laboratory measurements were carried out. Results: Frequency of aversion to milk consumption was 20% for CC genotype and 10% for TT + TC genotypes (p∈=∈0.03). The albumin-adjusted serum calcium was 2.325∈±∈0.09 mmol/L for CC genotype and 2.360∈±∈0.16 mmol/L for TT + TC genotypes (p∈=∈0.031). Bone mineral density (BMD; Z score) was lower in the CC than TT + TC genotypes, respectively, at the radius (0.105∈±∈1. 42 vs 0.406∈±∈1.32; p∈=∈0.038), at the total hip (-0.471∈±∈1.08 vs -0.170∈±∈1.09; p∈=∈0.041), and at the Ward's triangle (-0.334∈±∈0.87 vs -0.123∈±∈0.82; p∈=∈0.044). Conclusion: LCT 13910 C/T polymorphism is associated with decreased serum calcium level and lower BMD in postmenopausal women.

Original languageEnglish
Pages (from-to)639-645
Number of pages7
JournalOsteoporosis International
Volume20
Issue number4
DOIs
Publication statusPublished - Apr 2009

Fingerprint

Bone Density
Genotype
Calcium
Serum
Lactose Intolerance
Milk
Serum Albumin
Hip
Healthy Volunteers
Genes

Keywords

  • Bone mineral density
  • Lactose-phlorizin hydrolase
  • Osteoporosis
  • Polymorphism
  • Serum calcium

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

LCT 13910 C/T polymorphism, serum calcium, and bone mineral density in postmenopausal women. / Bácsi, K.; Kósa, J.; Lazáry, Á; Balla, B.; Horváth, H.; Kis, A.; Nagy, Z.; Takács, I.; Lakatos, P.; Speer, G.

In: Osteoporosis International, Vol. 20, No. 4, 04.2009, p. 639-645.

Research output: Contribution to journalArticle

Bácsi, K. ; Kósa, J. ; Lazáry, Á ; Balla, B. ; Horváth, H. ; Kis, A. ; Nagy, Z. ; Takács, I. ; Lakatos, P. ; Speer, G. / LCT 13910 C/T polymorphism, serum calcium, and bone mineral density in postmenopausal women. In: Osteoporosis International. 2009 ; Vol. 20, No. 4. pp. 639-645.
@article{b9c4e2f1ab9d41d28b71c763893f6031,
title = "LCT 13910 C/T polymorphism, serum calcium, and bone mineral density in postmenopausal women",
abstract = "Summary: LCT 13910 CC genotype is associated with lactose intolerance, a condition often resulting in reduced milk intake. Women with the CC genotype were found to have decreased serum calcium and reduced bone mineral density. Introduction: The CC genotype of the 13910 C/T polymorphism of the LCT gene is linked to lactose intolerance and low calcium intake. Methods: We studied 595 postmenopausal women, including 267 osteoporotic, 200 osteopenic, and 128 healthy subjects. Genotyping, osteodensitometry, and laboratory measurements were carried out. Results: Frequency of aversion to milk consumption was 20{\%} for CC genotype and 10{\%} for TT + TC genotypes (p∈=∈0.03). The albumin-adjusted serum calcium was 2.325∈±∈0.09 mmol/L for CC genotype and 2.360∈±∈0.16 mmol/L for TT + TC genotypes (p∈=∈0.031). Bone mineral density (BMD; Z score) was lower in the CC than TT + TC genotypes, respectively, at the radius (0.105∈±∈1. 42 vs 0.406∈±∈1.32; p∈=∈0.038), at the total hip (-0.471∈±∈1.08 vs -0.170∈±∈1.09; p∈=∈0.041), and at the Ward's triangle (-0.334∈±∈0.87 vs -0.123∈±∈0.82; p∈=∈0.044). Conclusion: LCT 13910 C/T polymorphism is associated with decreased serum calcium level and lower BMD in postmenopausal women.",
keywords = "Bone mineral density, Lactose-phlorizin hydrolase, Osteoporosis, Polymorphism, Serum calcium",
author = "K. B{\'a}csi and J. K{\'o}sa and {\'A} Laz{\'a}ry and B. Balla and H. Horv{\'a}th and A. Kis and Z. Nagy and I. Tak{\'a}cs and P. Lakatos and G. Speer",
year = "2009",
month = "4",
doi = "10.1007/s00198-008-0709-9",
language = "English",
volume = "20",
pages = "639--645",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer London",
number = "4",

}

TY - JOUR

T1 - LCT 13910 C/T polymorphism, serum calcium, and bone mineral density in postmenopausal women

AU - Bácsi, K.

AU - Kósa, J.

AU - Lazáry, Á

AU - Balla, B.

AU - Horváth, H.

AU - Kis, A.

AU - Nagy, Z.

AU - Takács, I.

AU - Lakatos, P.

AU - Speer, G.

PY - 2009/4

Y1 - 2009/4

N2 - Summary: LCT 13910 CC genotype is associated with lactose intolerance, a condition often resulting in reduced milk intake. Women with the CC genotype were found to have decreased serum calcium and reduced bone mineral density. Introduction: The CC genotype of the 13910 C/T polymorphism of the LCT gene is linked to lactose intolerance and low calcium intake. Methods: We studied 595 postmenopausal women, including 267 osteoporotic, 200 osteopenic, and 128 healthy subjects. Genotyping, osteodensitometry, and laboratory measurements were carried out. Results: Frequency of aversion to milk consumption was 20% for CC genotype and 10% for TT + TC genotypes (p∈=∈0.03). The albumin-adjusted serum calcium was 2.325∈±∈0.09 mmol/L for CC genotype and 2.360∈±∈0.16 mmol/L for TT + TC genotypes (p∈=∈0.031). Bone mineral density (BMD; Z score) was lower in the CC than TT + TC genotypes, respectively, at the radius (0.105∈±∈1. 42 vs 0.406∈±∈1.32; p∈=∈0.038), at the total hip (-0.471∈±∈1.08 vs -0.170∈±∈1.09; p∈=∈0.041), and at the Ward's triangle (-0.334∈±∈0.87 vs -0.123∈±∈0.82; p∈=∈0.044). Conclusion: LCT 13910 C/T polymorphism is associated with decreased serum calcium level and lower BMD in postmenopausal women.

AB - Summary: LCT 13910 CC genotype is associated with lactose intolerance, a condition often resulting in reduced milk intake. Women with the CC genotype were found to have decreased serum calcium and reduced bone mineral density. Introduction: The CC genotype of the 13910 C/T polymorphism of the LCT gene is linked to lactose intolerance and low calcium intake. Methods: We studied 595 postmenopausal women, including 267 osteoporotic, 200 osteopenic, and 128 healthy subjects. Genotyping, osteodensitometry, and laboratory measurements were carried out. Results: Frequency of aversion to milk consumption was 20% for CC genotype and 10% for TT + TC genotypes (p∈=∈0.03). The albumin-adjusted serum calcium was 2.325∈±∈0.09 mmol/L for CC genotype and 2.360∈±∈0.16 mmol/L for TT + TC genotypes (p∈=∈0.031). Bone mineral density (BMD; Z score) was lower in the CC than TT + TC genotypes, respectively, at the radius (0.105∈±∈1. 42 vs 0.406∈±∈1.32; p∈=∈0.038), at the total hip (-0.471∈±∈1.08 vs -0.170∈±∈1.09; p∈=∈0.041), and at the Ward's triangle (-0.334∈±∈0.87 vs -0.123∈±∈0.82; p∈=∈0.044). Conclusion: LCT 13910 C/T polymorphism is associated with decreased serum calcium level and lower BMD in postmenopausal women.

KW - Bone mineral density

KW - Lactose-phlorizin hydrolase

KW - Osteoporosis

KW - Polymorphism

KW - Serum calcium

UR - http://www.scopus.com/inward/record.url?scp=62149150989&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=62149150989&partnerID=8YFLogxK

U2 - 10.1007/s00198-008-0709-9

DO - 10.1007/s00198-008-0709-9

M3 - Article

VL - 20

SP - 639

EP - 645

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

IS - 4

ER -