LC-UV assay of tolperisone HCl from sustained release matrix tablets

Bernadett Stiedl, Dorottya Kovács-Kiss, K. Ludányi, Attila Bódis, I. Klebovich, I. Antal

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Tolperisone HCl is a central muscle relaxant, which was incorporated in a matrix system formulated with poly(ethylene oxide)-PEO, in order to achieve adequate gastric residence time. This tablet presents considerable analytical difficulties in the quantitative determination of the drug, because the PEO matrix causes significant increase of viscosity in the samples. Our purpose was to develop a reproducible sample preparation method, which is adapted from parameters of the in vitro dissolution test and validate an LC-UV analytical method, which allows good recovery of the drug (99.97%). The developed analytical method was suitable for quantitative analysis of tolperisone HCl in matrix tablets.

Original languageEnglish
JournalChromatographia
Volume71
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Jun 2010

Fingerprint

Tolperisone
Polyethylene oxides
Tablets
Assays
Central Muscle Relaxants
Ethylene Oxide
Viscosity
Pharmaceutical Preparations
Stomach
Dissolution
Recovery
Chemical analysis

Keywords

  • Column liquid chromatography
  • Poly(ethylene oxide)
  • Sustained release matrix tablet
  • Tolperisone HCl
  • UV detection

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

LC-UV assay of tolperisone HCl from sustained release matrix tablets. / Stiedl, Bernadett; Kovács-Kiss, Dorottya; Ludányi, K.; Bódis, Attila; Klebovich, I.; Antal, I.

In: Chromatographia, Vol. 71, No. SUPPL. 1, 06.2010.

Research output: Contribution to journalArticle

Stiedl, Bernadett ; Kovács-Kiss, Dorottya ; Ludányi, K. ; Bódis, Attila ; Klebovich, I. ; Antal, I. / LC-UV assay of tolperisone HCl from sustained release matrix tablets. In: Chromatographia. 2010 ; Vol. 71, No. SUPPL. 1.
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