LC enantioseparation of β-amino acids on a crown ether-based stationary phase

Robert Berkecz, István Ilisz, Zoltán Pataj, Ferenc Fülöp, Hee Jung Choi, Myung Ho Hyun, Antal Péter

Research output: Contribution to journalArticle

11 Citations (Scopus)


Reversed-phase high-performance liquid chromatographic methods were developed for the enantioseparation of ten unusual β-3-homo-amino acids. The underivatized analytes were separated on a chiral stationary phase containing (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid as chiral selector. The effects of organic and acidic modifiers and the mobile phase composition on the separation were investigated. The structures of the substituents in the β position substantially influenced the retention and resolution. The elution sequence was determined in some cases: the S enantiomers eluted before the R enantiomers.

Original languageEnglish
Pages (from-to)S13-S18
Issue numberSUPPL. 1
Publication statusPublished - Oct 1 2008


  • (+)-(18-Crown-6)-2, 3,11,12-tetracarboxylic acid-based chiral stationary phase
  • Column liquid chromatography
  • β-3-Homo-amino acids

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'LC enantioseparation of β-amino acids on a crown ether-based stationary phase'. Together they form a unique fingerprint.

  • Cite this