Lateralized rhythmic acoustic stimulation during daytime NREM sleep enhances slow waves

Péter Simor, Emilie Steinbach, Tamás Nagy, Médhi Gilson, Juliane Farthouat, Rémy Schmitz, Ferenc Gombos, Péter P. Ujma, Miklós Pamula, R. Bódizs, Philippe Peigneux

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Abstract

Slow wave sleep (SWS) is characterized by the predominance of delta waves and slow oscillations, reflecting the synchronized activity of large cortical neuronal populations. Amongst other functions, SWS plays a crucial role in the restorative capacity of sleep. Rhythmic acoustic stimulation (RAS) during SWS has been shown a cost-effective method to enhance slow wave activity. Slow wave activity can be expressed in a region-specific manner as a function of previous waking activity. However, it is unclear whether slow waves can be enhanced in a region-specific manner using RAS. We investigated the effects of unilaterally presented rhythmic acoustic sound patterns on sleep electroencephalographic (EEG) oscillations. Thirty-five participants received during SWS 12-second long rhythmic bursts of pink noise (at a rate of 1 Hz) that alternated with non-stimulated, silent periods, unilaterally delivered into one of the ears of the participants. As expected, RAS enhanced delta power, especially in its low-frequency components between 0.75 and 2.25 Hz. However, increased slow oscillatory activity was apparent in both hemispheres regardless of the side of the stimulation. The most robust increases in slow oscillatory activity appeared during the first 3-4 seconds of the stimulation period. Furthermore, a short-lasting increase in theta and sigma power was evidenced immediately after the first pulse of the stimulation sequences. Our findings indicate that lateralized RAS has a strong potential to globally enhance slow waves during daytime naps. The lack of localized effects suggests that slow waves are triggered by the ascending reticular system and not directly by specific auditory pathways.

Original languageEnglish
JournalSleep
Volume41
Issue number12
DOIs
Publication statusPublished - Dec 1 2018

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Acoustic Stimulation
Sleep
Auditory Pathways
Acoustics
Ear
Costs and Cost Analysis
Population

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)

Cite this

Simor, P., Steinbach, E., Nagy, T., Gilson, M., Farthouat, J., Schmitz, R., ... Peigneux, P. (2018). Lateralized rhythmic acoustic stimulation during daytime NREM sleep enhances slow waves. Sleep, 41(12). https://doi.org/10.1093/sleep/zsy176

Lateralized rhythmic acoustic stimulation during daytime NREM sleep enhances slow waves. / Simor, Péter; Steinbach, Emilie; Nagy, Tamás; Gilson, Médhi; Farthouat, Juliane; Schmitz, Rémy; Gombos, Ferenc; Ujma, Péter P.; Pamula, Miklós; Bódizs, R.; Peigneux, Philippe.

In: Sleep, Vol. 41, No. 12, 01.12.2018.

Research output: Contribution to journalArticle

Simor, P, Steinbach, E, Nagy, T, Gilson, M, Farthouat, J, Schmitz, R, Gombos, F, Ujma, PP, Pamula, M, Bódizs, R & Peigneux, P 2018, 'Lateralized rhythmic acoustic stimulation during daytime NREM sleep enhances slow waves', Sleep, vol. 41, no. 12. https://doi.org/10.1093/sleep/zsy176
Simor P, Steinbach E, Nagy T, Gilson M, Farthouat J, Schmitz R et al. Lateralized rhythmic acoustic stimulation during daytime NREM sleep enhances slow waves. Sleep. 2018 Dec 1;41(12). https://doi.org/10.1093/sleep/zsy176
Simor, Péter ; Steinbach, Emilie ; Nagy, Tamás ; Gilson, Médhi ; Farthouat, Juliane ; Schmitz, Rémy ; Gombos, Ferenc ; Ujma, Péter P. ; Pamula, Miklós ; Bódizs, R. ; Peigneux, Philippe. / Lateralized rhythmic acoustic stimulation during daytime NREM sleep enhances slow waves. In: Sleep. 2018 ; Vol. 41, No. 12.
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