Lateral organization of endocytic machinery in dendritic spines

B. Rácz, Thomas A. Blanpied, Michael D. Ehlers, Richard J. Weinberg

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Postsynaptic membrane trafficking plays an important role in synaptic plasticity, but the organization of trafficking machinery within dendritic spines is poorly understood. We use immunocytochemical analysis of rat hippocampal neurons to show that proteins mediating endocytosis are systematically arrayed within dendritic spines, tangential to the synapse. Thus, previously unrecognized lateral domains of the spine organize endocytic protein machinery at sites removed from the postsynaptic density.

Original languageEnglish
Pages (from-to)917-918
Number of pages2
JournalNature Neuroscience
Volume7
Issue number9
DOIs
Publication statusPublished - Sep 2004

Fingerprint

Dendritic Spines
Post-Synaptic Density
Neuronal Plasticity
Endocytosis
Synapses
Proteins
Spine
Neurons
Membranes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lateral organization of endocytic machinery in dendritic spines. / Rácz, B.; Blanpied, Thomas A.; Ehlers, Michael D.; Weinberg, Richard J.

In: Nature Neuroscience, Vol. 7, No. 9, 09.2004, p. 917-918.

Research output: Contribution to journalArticle

Rácz, B, Blanpied, TA, Ehlers, MD & Weinberg, RJ 2004, 'Lateral organization of endocytic machinery in dendritic spines', Nature Neuroscience, vol. 7, no. 9, pp. 917-918. https://doi.org/10.1038/nn1303
Rácz, B. ; Blanpied, Thomas A. ; Ehlers, Michael D. ; Weinberg, Richard J. / Lateral organization of endocytic machinery in dendritic spines. In: Nature Neuroscience. 2004 ; Vol. 7, No. 9. pp. 917-918.
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