Lateral hypothalamic feeding mechanisms: Iontophoretic effects of kainic acid, ibotenic acid and 6-hydroxydopamine

L. Lénárd, G. Jandö, Z. Karädi, A. Hajnal, P. Sändor

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

In order to study hunger motivated behavior kainic acid (KA), ibotenic acid (IB) and 6-hydroxydopamine (6-OHDA) were iontophoretically applied to the lateral hypothalamus of rats. Neurotoxins at concentrations between 20-120 mMol were applied with 5-20 μA current for 5-10 min. Tip diameter of glass micropipettes varied between 10-50 μ. Application of KA, IB and 6-OHDA caused temporary body weight loss, hypophagia and hypodipsia. Effects were dose dependent: correlation was found between current strength, tip diameter of pipettes, concentrations of neurotoxins and the extent of cellular damage. Aphagic and adipsic symptoms and the death of animals were only observed after extensive LH lesions. There was no significant difference in food consumption after 24 hr deprivation among groups. Water deprivation and extracellular or intracellular dehydration resulted in a considerable increase in water intake in all animals, however, consumption in lesioned rats was lower than that of controls. These water regulatory disturbances in 6-OHDA treated animals were somewhat less severe. Results show that the bilateral cellular microlesions of the LH and damage of dopaminergic (DA) elements with 6-OHDA both cause disturbances of feeding behavior. Although the severity of symptoms in some respects depends upon the nature of neurotoxic treatment, the basic consequences are essentially similar. It is suggested that the LH "feeding center" and the ascending DA pathways represent a single system involved in the organization of hunger motivated behavior.

Original languageEnglish
Pages (from-to)847-856
Number of pages10
JournalBrain Research Bulletin
Volume20
Issue number6
DOIs
Publication statusPublished - 1988

Fingerprint

Ibotenic Acid
Kainic Acid
Oxidopamine
Hunger
Neurotoxins
Lateral Hypothalamic Area
Water Deprivation
Feeding Behavior
Dehydration
Drinking
Glass
Weight Loss
Body Weight
Food
Water

Keywords

  • 6-Hydroxydopamine
  • Hunger
  • Ibotenic acid
  • Kainic acid
  • Lateral hypothalamus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lateral hypothalamic feeding mechanisms : Iontophoretic effects of kainic acid, ibotenic acid and 6-hydroxydopamine. / Lénárd, L.; Jandö, G.; Karädi, Z.; Hajnal, A.; Sändor, P.

In: Brain Research Bulletin, Vol. 20, No. 6, 1988, p. 847-856.

Research output: Contribution to journalArticle

Lénárd, L. ; Jandö, G. ; Karädi, Z. ; Hajnal, A. ; Sändor, P. / Lateral hypothalamic feeding mechanisms : Iontophoretic effects of kainic acid, ibotenic acid and 6-hydroxydopamine. In: Brain Research Bulletin. 1988 ; Vol. 20, No. 6. pp. 847-856.
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