According to the definition latent autoimmune diabetes in adults can be diagnosed if the desease starts at 35 years of age or later, no need for insulin in a time frame at least six months, and islet specific autoantibodies (ICA, GADA) are present in the patient's serum. Based on the immunogenetic studies and the progressive loss of insulin secretion the authors suggest that LADA belongs to the clinical spectrum of type 1 diabetes mellitus of autoimmune origin. At least 10% of type 2 diabetic patients diagnosed on clinical ground have LADA. The differentiation between type 2 diabetes and LADA is important. Partly because of the early insulin dependency of these patients. And also from a scientific point of view, as a group of type 2 diabetic patients diagnosed only by clinical criteria is polluted by diabetes mellitus of autoimmune origin and the results of the genetic or intervention studies can be influenced by this fact.
|Number of pages||5|
|Publication status||Published - Dec 1 2010|
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