Latency type-dependent modulation of Epstein-Barr virus-encoded latent membrane protein 1 expression by type I interferons in B cells

Daniel Salamon, Monika Adori, Dorina Ujvari, Liang Wu, Lorand L. Kis, Harsha S. Madapura, Noemi Nagy, George Klein, Eva Klein

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We report that type I interferons (IFNs) upregulate latent membrane protein 1 (LMP-1) expression by direct activation of the ED-L1 promoter in several Epstein-Barr virus (EBV)-carrying Burkitt's lymphoma lines. In EBV-infected primary B cells, IFN-_ transiently upregulates LMP-1 mRNA, but not protein levels, followed by downregulation of both, suggesting a novel antiproliferative mechanism of type I IFNs. Furthermore, our results may explain the expression of LMP-1 in memory B cells of systemic lupus erythematosus patients.

Original languageEnglish
Pages (from-to)4701-4707
Number of pages7
JournalJournal of Virology
Volume86
Issue number8
DOIs
Publication statusPublished - Apr 2012

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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