Late-onset Niemann–Pick disease type C overlapping with frontotemporal dementia syndromes: a case report

Nóra Balázs, Dániel Milanovich, Csilla Hornyák, Dániel Bereczki, Tibor Kovács

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The diagnosis of adult-onset Niemann–Pick disease type C (NPC) could be difficult because its primary symptoms [dementia and vertical supranuclear gaze palsy (VSGP)] are mainly seen in neurodegenerative dementias and progressive supranuclear palsy (PSP). Our patient with dementia and asymmetric parkinsonism resembled corticobasal syndrome and after the appearance of VSGP, the criteria of PSP were fulfilled too. Cerebellar symptoms appeared late during the course of the disease, leading to the diagnosis of NPC at the age of 59 years.

Original languageEnglish
Pages (from-to)1501-1504
Number of pages4
JournalJournal of neural transmission
Volume126
Issue number11
DOIs
Publication statusPublished - Nov 1 2019

Keywords

  • Corticobasal syndrome
  • Frontotemporal dementia
  • Niemann–Pick disease type C
  • Progressive supranuclear palsy
  • Vertical supranuclear gaze palsy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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