Late hyponatremia in premature infants: Role of aldosterone and arginine vasopressin

E. Sulyok, L. Kovács, B. Lichardus, N. Michajlovskij, V. Lehotska, V. Némethova, L. Varga, T. Ertl

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

To assess the possible involvement of arginine vasopressin in the pathogenesis of late hyponatremia in preterm infants, serial measurements of sodium balance, fractional sodium excretion, plasma and urine osmolality and sodium concentration, and urinary aldosterone and arginine vasopressin excretion were performed at weekly intervals in nine healthy preterm infants. During the course of late hyponatremia, there was a significant increase in urinary aldosterone and arginine vasopressin excretion, from 0.94±0.16 to 4.30±0.76 μg/day and from 0.38±0.08 to 1.19±0.26 ng/day, respectively, from the first to the fourth to fifth weeks. A significant negative correlation was found between fractional sodium excretion and urinary aldosterone excretion. Aldosterone excretion, however, correlated positively with urinary arginine vasopressin excretion in seven of the nine infants. The parallel increase in urinary aldosterone and arginine vasopressin excretion in salt-losing premature infants may occur in response to the protracted contraction of the extracellular fluid compartment, and may contribute to the restoration of volume in the body fluid compartments and to the development of late hyponatremia.

Original languageEnglish
Pages (from-to)990-994
Number of pages5
JournalThe Journal of Pediatrics
Volume106
Issue number6
DOIs
Publication statusPublished - Jun 1985

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Late hyponatremia in premature infants: Role of aldosterone and arginine vasopressin'. Together they form a unique fingerprint.

  • Cite this

    Sulyok, E., Kovács, L., Lichardus, B., Michajlovskij, N., Lehotska, V., Némethova, V., Varga, L., & Ertl, T. (1985). Late hyponatremia in premature infants: Role of aldosterone and arginine vasopressin. The Journal of Pediatrics, 106(6), 990-994. https://doi.org/10.1016/S0022-3476(85)80256-0