Late bedtime is associated with decreased hippocampal volume in young healthy subjects

Diána Kuperczkó, Gábor Perlaki, Béla Faludi, Gergely Orsi, Anna Altbacker, Norbert Kovács, Tamás Dóczi, Sámuel Komoly, Attila Schwarcz, Zsófia Clemens, József Janszky

Research output: Contribution to journalArticle

6 Citations (Scopus)


Hippocampal volume loss has been described in several pathological conditions including sleep disorders. Whether differences in normal sleep are associated with differences in hippocampal volume is unknown. Here we designed a study to assess volume of the hippocampus with regard to bedtime, wake up time and sleep duration in 90 healthy university students. To assess hippocampal volumes we applied semi-automatic user-independent magnetic resonance volumetry. We found a significant association between delayed bedtime and smaller hippocampal volumes, a non-significant tendency for smaller hippocampal volumes in the late wake up time group and significantly smaller hippocampal volumes for both short and long sleepers. These results suggest the importance of adequate sleep timing and especially bedtime in determining hippocampal volume.

Original languageEnglish
Pages (from-to)68-75
Number of pages8
JournalSleep and Biological Rhythms
Issue number1
Publication statusPublished - Jan 1 2015


  • Bedtime
  • Hippocampus
  • Sleep
  • Sleep duration
  • Slow wave sleep

ASJC Scopus subject areas

  • Physiology
  • Neuropsychology and Physiological Psychology
  • Neurology
  • Physiology (medical)

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