Lasting impact of a single benzpyrene treatment in pre-natal and growing age on the thymic glucocorticoid receptors of rats

G. Csaba, Ágnes Inczefi-Gonda, Sz Szeberényi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

1. 1. Rats exposed to benzpyrene in utero at 19 days of pre-natal life showed a relative decrease in the number of thymic glucocorticoid receptors at 6 weeks of age. 2. 2. Primary exposure to benzpyrene at 6 weeks of age had a similar effect on females 4 weeks later, but did not change the glucocorticoid receptor number of males. 3. 3. In utero exposure accounted for an increase in the fetal cytochrome P450 level within 1 day, whereas exposure at 6 weeks of age did not change it within 4 weeks. 4. 4. It appears that exposure to benzpyrene gives rise to a faulty imprinting of the thymic glucocorticoid receptor in both fetal and growing age, to judge from a lasting change in the receptor number.

Original languageEnglish
Pages (from-to)815-818
Number of pages4
JournalGeneral Pharmacology
Volume22
Issue number5
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Pharmacology

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