Landing of immune receptors and signal proteins on lipid rafts

A safe way to be spatio-temporally coordinated?

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In the past decade one of the cell biology's breakthroughs was discovery of membrane microdomains (rafts, caveolae) and recognition of their important in cellular signaling and protein traffic. In the present minireview a short comprehensive overview is given about physico-chemical, structural and functional properties of rafts. In addition to the classical immunochemical techniques the latest physcial and biophysical technologies that can be used to study these microdomains are also described briefly. The funcational significance of rafts in signaling of multichain immune recognition receptors (MIRRs), the IL-2R and ErbB family factor receptors is also discussed herein together with the still open questions and future prospects of the raft hypothesis.

Original languageEnglish
Pages (from-to)3-15
Number of pages13
JournalImmunology Letters
Volume82
Issue number1-2
DOIs
Publication statusPublished - Jun 3 2002

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Membrane Microdomains
Caveolae
Cell Biology
Technology
Lipids
Proteins

Keywords

  • Detergent resistance
  • Immune synapses
  • Lipid rafts
  • MIRR
  • Protein mobility
  • Scanning microscopy
  • Signal transduction

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

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title = "Landing of immune receptors and signal proteins on lipid rafts: A safe way to be spatio-temporally coordinated?",
abstract = "In the past decade one of the cell biology's breakthroughs was discovery of membrane microdomains (rafts, caveolae) and recognition of their important in cellular signaling and protein traffic. In the present minireview a short comprehensive overview is given about physico-chemical, structural and functional properties of rafts. In addition to the classical immunochemical techniques the latest physcial and biophysical technologies that can be used to study these microdomains are also described briefly. The funcational significance of rafts in signaling of multichain immune recognition receptors (MIRRs), the IL-2R and ErbB family factor receptors is also discussed herein together with the still open questions and future prospects of the raft hypothesis.",
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