Lamotrigine decreases EEG synchronization in a use-dependent manner in patients with idiopathic generalized epilepsy

B. Clemens, P. Piros, M. Bessenyei, K. Hollódy

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: To investigate the quantitative EEG effects of lamotrigine (LTG) monotherapy. Hypothesis: LTG was predicted to decrease thalamo-cortical neuronal synchronization in idiopathic generalized epilepsy (IGE). Methods: Waking EEG background activity of 19 IGE patients was investigated before treatment and in the course of LTG monotherapy. Raw absolute power (RAP), raw percent power (RRP), and raw mean frequency (RMF) were computed for 19 electrodes and four frequency bands (delta = 1.5-3.5 Hz, theta = 3.5-7.5 Hz, alpha = 7.5-12.5 Hz, and beta = 12.5-25.0 Hz). Inter- and intrahemispheric coherence was computed for eight electrode pairs and the four frequency bands. In addition, scalp-averages were calculated for each variable. Group differences were computed by means of nonparametric statistics including correction for multiple comparisons. Results: Main results were decreased delta and theta RAP (p <0.05 for scalp-averages). LTG compressed the delta, theta, and alpha RAP datasets, reducing the upper limit of the scatter in particular. Spearman r-values indicated marked correlation between the starting values (RAPuntreated) and the LTG-related decrease (RAPtreated - RAPuntreated) in three bands: delta (r = -0.72; p = 0.0005), theta (r = -0.59; p = 0.007), and alpha (r = -0.61; p = 0.006). Thus, the greater the baseline neuronal synchronization, the marked the dampening effect of LTG on it. The remaining findings were decreased theta RRP, theta RMF, and increased alpha RMF (p <0.05 for scalp-averages). The electrode-related changes were small but topographically consistent across the 19 electrode sites. LTG did not affect coherence. Conclusions: 1. LTG partially normalized the spectral composition of EEG background activity. LTG decreased pathological thalamo-cortical synchronization in use-dependent manner. 2. LTG did not cause quantitative EEG alterations suggesting worsening of the physiological brain functions. Instead, its profile suggested a mild psychostimulant effect. Significance: The results contribute to the understanding of the effect of LTG at the network level.

Original languageEnglish
Pages (from-to)910-917
Number of pages8
JournalClinical Neurophysiology
Volume118
Issue number4
DOIs
Publication statusPublished - Apr 2007

Fingerprint

Electroencephalography
Electrodes
Cortical Synchronization
Scalp
Idiopathic Generalized Epilepsy
lamotrigine
Nonparametric Statistics
Brain

Keywords

  • Idiopathic generalized epilepsy
  • Lamotrigine
  • Quantitative EEG

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

Cite this

Lamotrigine decreases EEG synchronization in a use-dependent manner in patients with idiopathic generalized epilepsy. / Clemens, B.; Piros, P.; Bessenyei, M.; Hollódy, K.

In: Clinical Neurophysiology, Vol. 118, No. 4, 04.2007, p. 910-917.

Research output: Contribution to journalArticle

@article{6ee6bae756a44c15a355b75e8c88422f,
title = "Lamotrigine decreases EEG synchronization in a use-dependent manner in patients with idiopathic generalized epilepsy",
abstract = "Objective: To investigate the quantitative EEG effects of lamotrigine (LTG) monotherapy. Hypothesis: LTG was predicted to decrease thalamo-cortical neuronal synchronization in idiopathic generalized epilepsy (IGE). Methods: Waking EEG background activity of 19 IGE patients was investigated before treatment and in the course of LTG monotherapy. Raw absolute power (RAP), raw percent power (RRP), and raw mean frequency (RMF) were computed for 19 electrodes and four frequency bands (delta = 1.5-3.5 Hz, theta = 3.5-7.5 Hz, alpha = 7.5-12.5 Hz, and beta = 12.5-25.0 Hz). Inter- and intrahemispheric coherence was computed for eight electrode pairs and the four frequency bands. In addition, scalp-averages were calculated for each variable. Group differences were computed by means of nonparametric statistics including correction for multiple comparisons. Results: Main results were decreased delta and theta RAP (p <0.05 for scalp-averages). LTG compressed the delta, theta, and alpha RAP datasets, reducing the upper limit of the scatter in particular. Spearman r-values indicated marked correlation between the starting values (RAPuntreated) and the LTG-related decrease (RAPtreated - RAPuntreated) in three bands: delta (r = -0.72; p = 0.0005), theta (r = -0.59; p = 0.007), and alpha (r = -0.61; p = 0.006). Thus, the greater the baseline neuronal synchronization, the marked the dampening effect of LTG on it. The remaining findings were decreased theta RRP, theta RMF, and increased alpha RMF (p <0.05 for scalp-averages). The electrode-related changes were small but topographically consistent across the 19 electrode sites. LTG did not affect coherence. Conclusions: 1. LTG partially normalized the spectral composition of EEG background activity. LTG decreased pathological thalamo-cortical synchronization in use-dependent manner. 2. LTG did not cause quantitative EEG alterations suggesting worsening of the physiological brain functions. Instead, its profile suggested a mild psychostimulant effect. Significance: The results contribute to the understanding of the effect of LTG at the network level.",
keywords = "Idiopathic generalized epilepsy, Lamotrigine, Quantitative EEG",
author = "B. Clemens and P. Piros and M. Bessenyei and K. Holl{\'o}dy",
year = "2007",
month = "4",
doi = "10.1016/j.clinph.2006.11.016",
language = "English",
volume = "118",
pages = "910--917",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd",
number = "4",

}

TY - JOUR

T1 - Lamotrigine decreases EEG synchronization in a use-dependent manner in patients with idiopathic generalized epilepsy

AU - Clemens, B.

AU - Piros, P.

AU - Bessenyei, M.

AU - Hollódy, K.

PY - 2007/4

Y1 - 2007/4

N2 - Objective: To investigate the quantitative EEG effects of lamotrigine (LTG) monotherapy. Hypothesis: LTG was predicted to decrease thalamo-cortical neuronal synchronization in idiopathic generalized epilepsy (IGE). Methods: Waking EEG background activity of 19 IGE patients was investigated before treatment and in the course of LTG monotherapy. Raw absolute power (RAP), raw percent power (RRP), and raw mean frequency (RMF) were computed for 19 electrodes and four frequency bands (delta = 1.5-3.5 Hz, theta = 3.5-7.5 Hz, alpha = 7.5-12.5 Hz, and beta = 12.5-25.0 Hz). Inter- and intrahemispheric coherence was computed for eight electrode pairs and the four frequency bands. In addition, scalp-averages were calculated for each variable. Group differences were computed by means of nonparametric statistics including correction for multiple comparisons. Results: Main results were decreased delta and theta RAP (p <0.05 for scalp-averages). LTG compressed the delta, theta, and alpha RAP datasets, reducing the upper limit of the scatter in particular. Spearman r-values indicated marked correlation between the starting values (RAPuntreated) and the LTG-related decrease (RAPtreated - RAPuntreated) in three bands: delta (r = -0.72; p = 0.0005), theta (r = -0.59; p = 0.007), and alpha (r = -0.61; p = 0.006). Thus, the greater the baseline neuronal synchronization, the marked the dampening effect of LTG on it. The remaining findings were decreased theta RRP, theta RMF, and increased alpha RMF (p <0.05 for scalp-averages). The electrode-related changes were small but topographically consistent across the 19 electrode sites. LTG did not affect coherence. Conclusions: 1. LTG partially normalized the spectral composition of EEG background activity. LTG decreased pathological thalamo-cortical synchronization in use-dependent manner. 2. LTG did not cause quantitative EEG alterations suggesting worsening of the physiological brain functions. Instead, its profile suggested a mild psychostimulant effect. Significance: The results contribute to the understanding of the effect of LTG at the network level.

AB - Objective: To investigate the quantitative EEG effects of lamotrigine (LTG) monotherapy. Hypothesis: LTG was predicted to decrease thalamo-cortical neuronal synchronization in idiopathic generalized epilepsy (IGE). Methods: Waking EEG background activity of 19 IGE patients was investigated before treatment and in the course of LTG monotherapy. Raw absolute power (RAP), raw percent power (RRP), and raw mean frequency (RMF) were computed for 19 electrodes and four frequency bands (delta = 1.5-3.5 Hz, theta = 3.5-7.5 Hz, alpha = 7.5-12.5 Hz, and beta = 12.5-25.0 Hz). Inter- and intrahemispheric coherence was computed for eight electrode pairs and the four frequency bands. In addition, scalp-averages were calculated for each variable. Group differences were computed by means of nonparametric statistics including correction for multiple comparisons. Results: Main results were decreased delta and theta RAP (p <0.05 for scalp-averages). LTG compressed the delta, theta, and alpha RAP datasets, reducing the upper limit of the scatter in particular. Spearman r-values indicated marked correlation between the starting values (RAPuntreated) and the LTG-related decrease (RAPtreated - RAPuntreated) in three bands: delta (r = -0.72; p = 0.0005), theta (r = -0.59; p = 0.007), and alpha (r = -0.61; p = 0.006). Thus, the greater the baseline neuronal synchronization, the marked the dampening effect of LTG on it. The remaining findings were decreased theta RRP, theta RMF, and increased alpha RMF (p <0.05 for scalp-averages). The electrode-related changes were small but topographically consistent across the 19 electrode sites. LTG did not affect coherence. Conclusions: 1. LTG partially normalized the spectral composition of EEG background activity. LTG decreased pathological thalamo-cortical synchronization in use-dependent manner. 2. LTG did not cause quantitative EEG alterations suggesting worsening of the physiological brain functions. Instead, its profile suggested a mild psychostimulant effect. Significance: The results contribute to the understanding of the effect of LTG at the network level.

KW - Idiopathic generalized epilepsy

KW - Lamotrigine

KW - Quantitative EEG

UR - http://www.scopus.com/inward/record.url?scp=33847363054&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847363054&partnerID=8YFLogxK

U2 - 10.1016/j.clinph.2006.11.016

DO - 10.1016/j.clinph.2006.11.016

M3 - Article

C2 - 17258504

AN - SCOPUS:33847363054

VL - 118

SP - 910

EP - 917

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 4

ER -