Laminar profile of spontaneous and evoked theta: Rhythmic modulation of cortical processing during word integration

Eric Halgren, Erik Kaestner, Ksenija Marinkovic, Sydney S. Cash, Chunmao Wang, Donald L. Schomer, Joseph R. Madsen, I. Ulbert

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Theta may play a central role during language understanding and other extended cognitive processing, providing an envelope for widespread integration of participating cortical areas. We used linear microelectrode arrays in epileptics to define the circuits generating theta in inferotemporal, perirhinal, entorhinal, prefrontal and anterior cingulate cortices. In all locations, theta was generated by excitatory current sinks in middle layers which receive predominantly feedforward inputs, alternating with sinks in superficial layers which receive mainly feedback/associative inputs. Baseline and event-related theta were generated by indistinguishable laminar profiles of transmembrane currents and unit-firing. Word presentation could reset theta phase, permitting theta to contribute to late event-related potentials, even when theta power decreases relative to baseline. Limited recordings during sentence reading are consistent with rhythmic theta activity entrained by a given word modulating the neural background for the following word. These findings show that theta occurs spontaneously, and can be momentarily suppressed, reset and synchronized by words. Theta represents an alternation between feedforward/divergent and associative/convergent processing modes that may temporally organize sustained processing and optimize the timing of memory formation. We suggest that words are initially encoded via a ventral feedforward stream which is lexicosemantic in the anteroventral temporal lobe; its arrival may trigger a widespread theta rhythm which integrates the word within a larger context.

Original languageEnglish
Pages (from-to)108-124
Number of pages17
JournalNeuropsychologia
Volume76
DOIs
Publication statusPublished - Sep 1 2015

Fingerprint

Theta Rhythm
Word Processing
Gyrus Cinguli
Microelectrodes
Temporal Lobe
Evoked Potentials
Reading
Language
Power (Psychology)

Keywords

  • Cingulate
  • Current-source density
  • Delta
  • Entorhinal
  • Feedback
  • Feedforward
  • Gamma
  • Inferotemporal
  • Perirhinal
  • Prefrontal

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Laminar profile of spontaneous and evoked theta : Rhythmic modulation of cortical processing during word integration. / Halgren, Eric; Kaestner, Erik; Marinkovic, Ksenija; Cash, Sydney S.; Wang, Chunmao; Schomer, Donald L.; Madsen, Joseph R.; Ulbert, I.

In: Neuropsychologia, Vol. 76, 01.09.2015, p. 108-124.

Research output: Contribution to journalArticle

Halgren, Eric ; Kaestner, Erik ; Marinkovic, Ksenija ; Cash, Sydney S. ; Wang, Chunmao ; Schomer, Donald L. ; Madsen, Joseph R. ; Ulbert, I. / Laminar profile of spontaneous and evoked theta : Rhythmic modulation of cortical processing during word integration. In: Neuropsychologia. 2015 ; Vol. 76. pp. 108-124.
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