Lactose intolerance but not lactose maldigestion is more frequent in patients with irritable bowel syndrome than in healthy controls: A meta-analysis

Péter Varjú, Noémi Gede, Zsolt Szakács, P. Hegyi, Irina Mihaela Cazacu, Dániel Pécsi, Anna Fábián, Zoltán Szepes, A. Vincze, Judit Tenk, M. Balaskó, Zoltán Rumbus, András Garami, Dezső Csupor, József Czimmer

Research output: Contribution to journalArticle

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Abstract

Background and Purpose: Irritable bowel syndrome (IBS) affects 10%-20% of the adult population and is characterized by abdominal symptoms without relevant organic disease. There are numerous clinical trials available investigating the relationship between IBS, lactose maldigestion (LM), and lactose intolerance (LI), but there have been no meta-analyses on this topic yet. We aimed to assess the prevalence of LM, objective and subjective (self-reported) LI in IBS patients compared to healthy controls (HC) without IBS. Methods: A systematic literature search was conducted up to 24 April 2018 in PubMed, Embase, and Cochrane Library. Adult IBS patients had to be diagnosed according to the Rome criteria or other well-defined criteria system. We enrolled controlled studies including healthy adult participants without IBS, as control group. Odds ratios with 95% confidence intervals were calculated. Key Results: Altogether 14 articles were suitable for statistical analyses. IBS patients reported themselves significantly more frequently lactose intolerant than HCs (odds ratio [OR] = 3.499; 95% confidence interval [CI] = 1.622-7.551). Generally, there was no significant difference in the prevalence of LM based on ingested lactose dose (OR = 1.122; 95% CI = 0.929-1.356) and test type (OR = 1.156; 95% CI = 0.985-1.356). However, significantly more IBS patients had objective LI (OR = 2.521; 95% CI = 1.280-4.965). Conclusions and Inferences: Lactose intolerance, but not LM is more frequent among patients with IBS compared to HCs. According to our results, IBS among other functional bowel disorders is a possible contributing factor of LI in people with LM.

Original languageEnglish
Article numbere13527
JournalNeurogastroenterology and Motility
DOIs
Publication statusAccepted/In press - Jan 1 2018

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Lactose Intolerance
Irritable Bowel Syndrome
Lactose
Meta-Analysis
Odds Ratio
Confidence Intervals
PubMed
Libraries
Healthy Volunteers
Clinical Trials

Keywords

  • irritable bowel syndrome
  • lactose intolerance
  • lactose maldigestion

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

Cite this

Lactose intolerance but not lactose maldigestion is more frequent in patients with irritable bowel syndrome than in healthy controls : A meta-analysis. / Varjú, Péter; Gede, Noémi; Szakács, Zsolt; Hegyi, P.; Cazacu, Irina Mihaela; Pécsi, Dániel; Fábián, Anna; Szepes, Zoltán; Vincze, A.; Tenk, Judit; Balaskó, M.; Rumbus, Zoltán; Garami, András; Csupor, Dezső; Czimmer, József.

In: Neurogastroenterology and Motility, 01.01.2018.

Research output: Contribution to journalArticle

Varjú, Péter ; Gede, Noémi ; Szakács, Zsolt ; Hegyi, P. ; Cazacu, Irina Mihaela ; Pécsi, Dániel ; Fábián, Anna ; Szepes, Zoltán ; Vincze, A. ; Tenk, Judit ; Balaskó, M. ; Rumbus, Zoltán ; Garami, András ; Csupor, Dezső ; Czimmer, József. / Lactose intolerance but not lactose maldigestion is more frequent in patients with irritable bowel syndrome than in healthy controls : A meta-analysis. In: Neurogastroenterology and Motility. 2018.
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T2 - A meta-analysis

AU - Varjú, Péter

AU - Gede, Noémi

AU - Szakács, Zsolt

AU - Hegyi, P.

AU - Cazacu, Irina Mihaela

AU - Pécsi, Dániel

AU - Fábián, Anna

AU - Szepes, Zoltán

AU - Vincze, A.

AU - Tenk, Judit

AU - Balaskó, M.

AU - Rumbus, Zoltán

AU - Garami, András

AU - Csupor, Dezső

AU - Czimmer, József

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