LAKTAT-GUANIDINUM ES LAKTAT-LAKTAT GYENGE KOLCSONHATASOK VIZES KOZEGBEN

Translated title of the contribution: Lactate-guanidinium and lactate-lactate weak interactions in aqueous solution

Research output: Contribution to journalArticle

Abstract

Spectropolarimetry was used to quantify the guanidinium-lactate and lactate-lactate equilibrium reactions. Association constants for the guanidinium-lactate and lactate-lactate formations are 6.11 and 1.12, respectively, in aqueous solution. The value 6.11 is certainly high among electrostatic interactions in water. This stability, however, can not account for the extremely strong lactate-protein binding, observed by NMR spectroscopy. The molar rotation coefficients for both the hetero-association and homo-association complexes are also calculated. The homo-associative lactate-lactate binding is the first such interaction, whose constant has been determined by spectropolarimetry in aqueous solution.

Original languageHungarian
Pages (from-to)119-122
Number of pages4
JournalActa pharmaceutica Hungarica
Volume65
Issue number4
Publication statusPublished - Jan 1 1995

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ASJC Scopus subject areas

  • Pharmaceutical Science

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