Lack of protective effect of adrenaline tolerance in haemorrhagic shock in conscious dogs

S. Nagy, A. Adamicza, K. Tarnoky

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Dogs were made tolerant to lethal doses of adrenaline by treatment with increasing doses of the hormone up to 1 mg/kg. The conscious animals were then subjected to haemorrhagic shock with a hypovolaemic period of 3 hours. Survival was 8/17 in the pretreated group and 15/18 in the control group. 12 of 29 dogs died during the adrenaline treatment. Plasma catecholamine levels were higher in the treated group before bleeding and also during hypovolaemia. Catecholamine induced myocardial lesions were found in the treated group. No evidence of a blunting of the sympathetic response or a protective effect in haemorrhagic shock was seen in adrenaline tolerance.

Original languageEnglish
Pages (from-to)159-166
Number of pages8
JournalActa Physiologica Hungarica
Volume62
Issue number2
Publication statusPublished - 1983

Fingerprint

Hemorrhagic Shock
Epinephrine
Hypovolemia
Dogs
Catecholamines
Hormones
Hemorrhage
Control Groups

ASJC Scopus subject areas

  • Physiology

Cite this

Lack of protective effect of adrenaline tolerance in haemorrhagic shock in conscious dogs. / Nagy, S.; Adamicza, A.; Tarnoky, K.

In: Acta Physiologica Hungarica, Vol. 62, No. 2, 1983, p. 159-166.

Research output: Contribution to journalArticle

@article{847312090f634a018da6d285112c5417,
title = "Lack of protective effect of adrenaline tolerance in haemorrhagic shock in conscious dogs",
abstract = "Dogs were made tolerant to lethal doses of adrenaline by treatment with increasing doses of the hormone up to 1 mg/kg. The conscious animals were then subjected to haemorrhagic shock with a hypovolaemic period of 3 hours. Survival was 8/17 in the pretreated group and 15/18 in the control group. 12 of 29 dogs died during the adrenaline treatment. Plasma catecholamine levels were higher in the treated group before bleeding and also during hypovolaemia. Catecholamine induced myocardial lesions were found in the treated group. No evidence of a blunting of the sympathetic response or a protective effect in haemorrhagic shock was seen in adrenaline tolerance.",
author = "S. Nagy and A. Adamicza and K. Tarnoky",
year = "1983",
language = "English",
volume = "62",
pages = "159--166",
journal = "Physiology International",
issn = "2498-602X",
publisher = "Akademiai Kiado",
number = "2",

}

TY - JOUR

T1 - Lack of protective effect of adrenaline tolerance in haemorrhagic shock in conscious dogs

AU - Nagy, S.

AU - Adamicza, A.

AU - Tarnoky, K.

PY - 1983

Y1 - 1983

N2 - Dogs were made tolerant to lethal doses of adrenaline by treatment with increasing doses of the hormone up to 1 mg/kg. The conscious animals were then subjected to haemorrhagic shock with a hypovolaemic period of 3 hours. Survival was 8/17 in the pretreated group and 15/18 in the control group. 12 of 29 dogs died during the adrenaline treatment. Plasma catecholamine levels were higher in the treated group before bleeding and also during hypovolaemia. Catecholamine induced myocardial lesions were found in the treated group. No evidence of a blunting of the sympathetic response or a protective effect in haemorrhagic shock was seen in adrenaline tolerance.

AB - Dogs were made tolerant to lethal doses of adrenaline by treatment with increasing doses of the hormone up to 1 mg/kg. The conscious animals were then subjected to haemorrhagic shock with a hypovolaemic period of 3 hours. Survival was 8/17 in the pretreated group and 15/18 in the control group. 12 of 29 dogs died during the adrenaline treatment. Plasma catecholamine levels were higher in the treated group before bleeding and also during hypovolaemia. Catecholamine induced myocardial lesions were found in the treated group. No evidence of a blunting of the sympathetic response or a protective effect in haemorrhagic shock was seen in adrenaline tolerance.

UR - http://www.scopus.com/inward/record.url?scp=0021047156&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021047156&partnerID=8YFLogxK

M3 - Article

C2 - 6670565

AN - SCOPUS:0021047156

VL - 62

SP - 159

EP - 166

JO - Physiology International

JF - Physiology International

SN - 2498-602X

IS - 2

ER -