Lack of prejunctional modulation of noradrenaline release by endogenous nitric oxide in guinea pig pulmonary artery

Attila Brassai, Katalin Makó, László Domjanschitz, B. Sperlágh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The regulation of noradrenaline (NA) release by endogenous endothelium-derived compounds was investigated in the isolated guinea pig pulmonary artery preloaded with [3H]NA. The radioactivity uptake, the basal and electrical field stimulation (10Hz, 2ms, 360 shocks) evoked release of [3H]NA was similar in arteries with intact endothelium and after removal of the endothelium. The wide selectivity nitric oxide (NO) synthase inhibitor N-ω-nitro-L-arginine (100μM) did not affect significantly the basal and stimulation-evoked release of [3H]NA in control and endothelium-denuded preparations. These results indicate that neither endogenous NO nor other compounds derived from the endothelium have substantial influence on the NA outflow from sympathetic nerves innervating the pulmonary artery.

Original languageEnglish
Pages (from-to)279-283
Number of pages5
JournalNeurochemistry International
Volume41
Issue number4
DOIs
Publication statusPublished - 2002

Fingerprint

Pulmonary Artery
Endothelium
Norepinephrine
Nitric Oxide
Guinea Pigs
Nitric Oxide Synthase
Radioactivity
Electric Stimulation
Arginine
Shock
Arteries

Keywords

  • Guinea pig
  • Nitric oxide
  • Noradrenaline
  • Pulmonary artery
  • Release

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Lack of prejunctional modulation of noradrenaline release by endogenous nitric oxide in guinea pig pulmonary artery. / Brassai, Attila; Makó, Katalin; Domjanschitz, László; Sperlágh, B.

In: Neurochemistry International, Vol. 41, No. 4, 2002, p. 279-283.

Research output: Contribution to journalArticle

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