Lack of hormonal influences on the gabaergic stimulation of growth hormone secretion in the neonatal rat

Z. Acs, A. Nemeskeri, Z. Mergl, G. Makara

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

GABA has been shown to stimulate pituitary growth hormone secretion in the neonatal but not in the adult rat. The disapparence of the GH stimulatory effect of GABA was studied in organ-cultured neonatal pituitaries and in pituitaries from rats treated neonatally with various hormones. The responsiveness of organ-cultured neonatal pituitaries to GABA and to TRH was diminished compared to that of the littermate controls. Treatment of the neonatal rats with adrenal and sexual steroids or thyroid hormones had no effect on the GABA elicited pituitary GH secretion. We conclude that the disappearance of GABAergic stimulation of GH secretion in the postnatal development is not influenced by the changes in the hormonal environment.

Original languageEnglish
Pages (from-to)191-196
Number of pages6
JournalNeuroendocrinology Letters
Volume15
Issue number3
Publication statusPublished - 1993

Fingerprint

gamma-Aminobutyric Acid
Growth Hormone
Thyroid Hormones
Steroids
Hormones

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

Lack of hormonal influences on the gabaergic stimulation of growth hormone secretion in the neonatal rat. / Acs, Z.; Nemeskeri, A.; Mergl, Z.; Makara, G.

In: Neuroendocrinology Letters, Vol. 15, No. 3, 1993, p. 191-196.

Research output: Contribution to journalArticle

@article{eb9df14ded7445cd93c0a78f681c5278,
title = "Lack of hormonal influences on the gabaergic stimulation of growth hormone secretion in the neonatal rat",
abstract = "GABA has been shown to stimulate pituitary growth hormone secretion in the neonatal but not in the adult rat. The disapparence of the GH stimulatory effect of GABA was studied in organ-cultured neonatal pituitaries and in pituitaries from rats treated neonatally with various hormones. The responsiveness of organ-cultured neonatal pituitaries to GABA and to TRH was diminished compared to that of the littermate controls. Treatment of the neonatal rats with adrenal and sexual steroids or thyroid hormones had no effect on the GABA elicited pituitary GH secretion. We conclude that the disappearance of GABAergic stimulation of GH secretion in the postnatal development is not influenced by the changes in the hormonal environment.",
author = "Z. Acs and A. Nemeskeri and Z. Mergl and G. Makara",
year = "1993",
language = "English",
volume = "15",
pages = "191--196",
journal = "Neuroendocrinology Letters",
issn = "0172-780X",
publisher = "Maghira and Maas Publications",
number = "3",

}

TY - JOUR

T1 - Lack of hormonal influences on the gabaergic stimulation of growth hormone secretion in the neonatal rat

AU - Acs, Z.

AU - Nemeskeri, A.

AU - Mergl, Z.

AU - Makara, G.

PY - 1993

Y1 - 1993

N2 - GABA has been shown to stimulate pituitary growth hormone secretion in the neonatal but not in the adult rat. The disapparence of the GH stimulatory effect of GABA was studied in organ-cultured neonatal pituitaries and in pituitaries from rats treated neonatally with various hormones. The responsiveness of organ-cultured neonatal pituitaries to GABA and to TRH was diminished compared to that of the littermate controls. Treatment of the neonatal rats with adrenal and sexual steroids or thyroid hormones had no effect on the GABA elicited pituitary GH secretion. We conclude that the disappearance of GABAergic stimulation of GH secretion in the postnatal development is not influenced by the changes in the hormonal environment.

AB - GABA has been shown to stimulate pituitary growth hormone secretion in the neonatal but not in the adult rat. The disapparence of the GH stimulatory effect of GABA was studied in organ-cultured neonatal pituitaries and in pituitaries from rats treated neonatally with various hormones. The responsiveness of organ-cultured neonatal pituitaries to GABA and to TRH was diminished compared to that of the littermate controls. Treatment of the neonatal rats with adrenal and sexual steroids or thyroid hormones had no effect on the GABA elicited pituitary GH secretion. We conclude that the disappearance of GABAergic stimulation of GH secretion in the postnatal development is not influenced by the changes in the hormonal environment.

UR - http://www.scopus.com/inward/record.url?scp=0027156064&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027156064&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0027156064

VL - 15

SP - 191

EP - 196

JO - Neuroendocrinology Letters

JF - Neuroendocrinology Letters

SN - 0172-780X

IS - 3

ER -