Lack of association between insulin-like growth factor I receptor G+3174A polymorphism and retinopathy of prematurity

Ádam Balogh, László Derzbach, Ádám Vannay, Barna Vásárhelyi

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22 Citations (Scopus)

Abstract

Background: Retinopathy of prematurity (ROP) is a potentially blinding eye disorder that affects premature infants. Insulin-like growth factor I (IGF-I) has been established as being necessary for vascular growth in the neonatal retina. Low IGF-I levels during the early postnatal days have been found to be predictive for ROP. The effects of IGF-I are mediated through IGF-I receptors (IGF-IR), which, in turn, suppress IGF-I production. The G+3174A polymorphism of the IGF-IR gene has been shown to be associated with low IGF-I levels. We tested the association of this IGF-IR polymorphism with ROP. Methods: We enrolled in the ROP group those infants (n=108) who had been treated with laser or cryo therapy due to ROP stage 2+ or 3 (n=91) or had a ROP stage 4 or 5 (n=17) (ROP group). The median gestational age of these infants was 28 weeks (range 24-35 weeks) and birth weight was 970 g (range 630 to 2,000 g). The distribution of IGFR-1 G+3174A genotype in the ROP group was compared to that in 120 gestational age-matched infants with ROP stage 1 or 2 not requiring intervention [gestational age 30 (range 24-37) weeks, birth weight 1,235 (640-1,960) g] (LBW group) and 164 term newborns [gestational age 39 (range 35-42) weeks, birth weight 3,450 (2,500-4,350) g] (term group). Genotyping was done using PCR-RFLP methods. Result: The prevalence of IGF-IR G+3174A polymorphism was the same in the ROP group, the LBW group and the term group, showing no association between this single-nucleotide polymorphism (SNP) and ROP. Conclusion: Our results do not support the hypothesis that the carrier state of IGF-IR G+3174A polymorphism has an impact on the risk of ROP in infants. A possible cause for the lack of association is that the rapid nutritional and metabolic changes during postnatal life have a greater effect on IGF-I levels than this SNP does.

Original languageEnglish
Pages (from-to)1035-1038
Number of pages4
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume244
Issue number8
DOIs
Publication statusPublished - Aug 2006

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Retinopathy of Prematurity
IGF Type 1 Receptor
Insulin-Like Growth Factor I
Gestational Age
Birth Weight
Single Nucleotide Polymorphism
Carrier State
Premature Infants
Restriction Fragment Length Polymorphisms
Blood Vessels
Retina
Lasers

Keywords

  • Genetic polymorphism
  • Insulin-like growth factor I
  • Pretem infant
  • Retinopathy of prematurity

ASJC Scopus subject areas

  • Ophthalmology

Cite this

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title = "Lack of association between insulin-like growth factor I receptor G+3174A polymorphism and retinopathy of prematurity",
abstract = "Background: Retinopathy of prematurity (ROP) is a potentially blinding eye disorder that affects premature infants. Insulin-like growth factor I (IGF-I) has been established as being necessary for vascular growth in the neonatal retina. Low IGF-I levels during the early postnatal days have been found to be predictive for ROP. The effects of IGF-I are mediated through IGF-I receptors (IGF-IR), which, in turn, suppress IGF-I production. The G+3174A polymorphism of the IGF-IR gene has been shown to be associated with low IGF-I levels. We tested the association of this IGF-IR polymorphism with ROP. Methods: We enrolled in the ROP group those infants (n=108) who had been treated with laser or cryo therapy due to ROP stage 2+ or 3 (n=91) or had a ROP stage 4 or 5 (n=17) (ROP group). The median gestational age of these infants was 28 weeks (range 24-35 weeks) and birth weight was 970 g (range 630 to 2,000 g). The distribution of IGFR-1 G+3174A genotype in the ROP group was compared to that in 120 gestational age-matched infants with ROP stage 1 or 2 not requiring intervention [gestational age 30 (range 24-37) weeks, birth weight 1,235 (640-1,960) g] (LBW group) and 164 term newborns [gestational age 39 (range 35-42) weeks, birth weight 3,450 (2,500-4,350) g] (term group). Genotyping was done using PCR-RFLP methods. Result: The prevalence of IGF-IR G+3174A polymorphism was the same in the ROP group, the LBW group and the term group, showing no association between this single-nucleotide polymorphism (SNP) and ROP. Conclusion: Our results do not support the hypothesis that the carrier state of IGF-IR G+3174A polymorphism has an impact on the risk of ROP in infants. A possible cause for the lack of association is that the rapid nutritional and metabolic changes during postnatal life have a greater effect on IGF-I levels than this SNP does.",
keywords = "Genetic polymorphism, Insulin-like growth factor I, Pretem infant, Retinopathy of prematurity",
author = "{\'A}dam Balogh and L{\'a}szl{\'o} Derzbach and {\'A}d{\'a}m Vannay and Barna V{\'a}s{\'a}rhelyi",
year = "2006",
month = "8",
doi = "10.1007/s00417-005-0203-4",
language = "English",
volume = "244",
pages = "1035--1038",
journal = "Graefe's Archive for Clinical and Experimental Ophthalmology",
issn = "0721-832X",
publisher = "Springer Verlag",
number = "8",

}

TY - JOUR

T1 - Lack of association between insulin-like growth factor I receptor G+3174A polymorphism and retinopathy of prematurity

AU - Balogh, Ádam

AU - Derzbach, László

AU - Vannay, Ádám

AU - Vásárhelyi, Barna

PY - 2006/8

Y1 - 2006/8

N2 - Background: Retinopathy of prematurity (ROP) is a potentially blinding eye disorder that affects premature infants. Insulin-like growth factor I (IGF-I) has been established as being necessary for vascular growth in the neonatal retina. Low IGF-I levels during the early postnatal days have been found to be predictive for ROP. The effects of IGF-I are mediated through IGF-I receptors (IGF-IR), which, in turn, suppress IGF-I production. The G+3174A polymorphism of the IGF-IR gene has been shown to be associated with low IGF-I levels. We tested the association of this IGF-IR polymorphism with ROP. Methods: We enrolled in the ROP group those infants (n=108) who had been treated with laser or cryo therapy due to ROP stage 2+ or 3 (n=91) or had a ROP stage 4 or 5 (n=17) (ROP group). The median gestational age of these infants was 28 weeks (range 24-35 weeks) and birth weight was 970 g (range 630 to 2,000 g). The distribution of IGFR-1 G+3174A genotype in the ROP group was compared to that in 120 gestational age-matched infants with ROP stage 1 or 2 not requiring intervention [gestational age 30 (range 24-37) weeks, birth weight 1,235 (640-1,960) g] (LBW group) and 164 term newborns [gestational age 39 (range 35-42) weeks, birth weight 3,450 (2,500-4,350) g] (term group). Genotyping was done using PCR-RFLP methods. Result: The prevalence of IGF-IR G+3174A polymorphism was the same in the ROP group, the LBW group and the term group, showing no association between this single-nucleotide polymorphism (SNP) and ROP. Conclusion: Our results do not support the hypothesis that the carrier state of IGF-IR G+3174A polymorphism has an impact on the risk of ROP in infants. A possible cause for the lack of association is that the rapid nutritional and metabolic changes during postnatal life have a greater effect on IGF-I levels than this SNP does.

AB - Background: Retinopathy of prematurity (ROP) is a potentially blinding eye disorder that affects premature infants. Insulin-like growth factor I (IGF-I) has been established as being necessary for vascular growth in the neonatal retina. Low IGF-I levels during the early postnatal days have been found to be predictive for ROP. The effects of IGF-I are mediated through IGF-I receptors (IGF-IR), which, in turn, suppress IGF-I production. The G+3174A polymorphism of the IGF-IR gene has been shown to be associated with low IGF-I levels. We tested the association of this IGF-IR polymorphism with ROP. Methods: We enrolled in the ROP group those infants (n=108) who had been treated with laser or cryo therapy due to ROP stage 2+ or 3 (n=91) or had a ROP stage 4 or 5 (n=17) (ROP group). The median gestational age of these infants was 28 weeks (range 24-35 weeks) and birth weight was 970 g (range 630 to 2,000 g). The distribution of IGFR-1 G+3174A genotype in the ROP group was compared to that in 120 gestational age-matched infants with ROP stage 1 or 2 not requiring intervention [gestational age 30 (range 24-37) weeks, birth weight 1,235 (640-1,960) g] (LBW group) and 164 term newborns [gestational age 39 (range 35-42) weeks, birth weight 3,450 (2,500-4,350) g] (term group). Genotyping was done using PCR-RFLP methods. Result: The prevalence of IGF-IR G+3174A polymorphism was the same in the ROP group, the LBW group and the term group, showing no association between this single-nucleotide polymorphism (SNP) and ROP. Conclusion: Our results do not support the hypothesis that the carrier state of IGF-IR G+3174A polymorphism has an impact on the risk of ROP in infants. A possible cause for the lack of association is that the rapid nutritional and metabolic changes during postnatal life have a greater effect on IGF-I levels than this SNP does.

KW - Genetic polymorphism

KW - Insulin-like growth factor I

KW - Pretem infant

KW - Retinopathy of prematurity

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U2 - 10.1007/s00417-005-0203-4

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