Lack of association between genetic risk loci for restless legs syndrome and multimorbidity

A. Szentkirályi, Henry Völzke, Wolfgang Hoffmann, Julianne Winkelmann, Klaus Berger

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Study Objectives: Multimorbidity is a risk factor for incident restless legs syndrome (RLS). In this relationship, the potential role of known genetic risk loci for RLS has not been studied. Our aim was to evaluate whether carriers of specific RLS risk alleles have higher comorbidity burden than noncarriers. Methods: The Dortmund Health Study (DHS) and the Study of Health in Pomerania (SHIP) are two independent cohort studies in Germany based on agestratified, random samples drawn from the respective population registers. DHS included 1,312 subjects and SHIP included 4,308 subjects. RLS status was assessed according to the RLS standard minimal criteria. A comorbidity index was calculated by summing the scores of the following conditions: diabetes, hypertension, myocardial infarction, obesity, stroke, cancer, renal disease, anemia, depression, thyroid disease, and migraine. Thirteen single nucleotide polymorphisms (SNP) previously associated with elevated risk of RLS were genotyped. Analyses were carried out on the pooled sample of the two studies. Results: The mean age was 50.4 ± 15.9 y, and the proportion of women was 51.4%. The mean number of comorbid conditions was 1.5 ± 1.3. In multivariable regression, the mean number of comorbidities was not significantly different between carriers of any of the RLS risk alleles and noncarriers either in the total pooled sample or in those having RLS symptoms. Conclusions: Based on these results it is unlikely that known genetic risk factors for RLS would lead to increased multimorbidity.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalSleep
Volume39
Issue number1
DOIs
Publication statusPublished - 2016

Fingerprint

Restless Legs Syndrome
Genetic Loci
Comorbidity
Health
Alleles
Kidney Neoplasms
Thyroid Diseases
Migraine Disorders
Single Nucleotide Polymorphism
Germany
Registries
Anemia
Cohort Studies
Obesity
Stroke
Myocardial Infarction
Depression
Hypertension

Keywords

  • Multimorbidity
  • Restless legs syndrome
  • Risk alleles

ASJC Scopus subject areas

  • Physiology (medical)
  • Clinical Neurology

Cite this

Lack of association between genetic risk loci for restless legs syndrome and multimorbidity. / Szentkirályi, A.; Völzke, Henry; Hoffmann, Wolfgang; Winkelmann, Julianne; Berger, Klaus.

In: Sleep, Vol. 39, No. 1, 2016, p. 111-115.

Research output: Contribution to journalArticle

Szentkirályi, A. ; Völzke, Henry ; Hoffmann, Wolfgang ; Winkelmann, Julianne ; Berger, Klaus. / Lack of association between genetic risk loci for restless legs syndrome and multimorbidity. In: Sleep. 2016 ; Vol. 39, No. 1. pp. 111-115.
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N2 - Study Objectives: Multimorbidity is a risk factor for incident restless legs syndrome (RLS). In this relationship, the potential role of known genetic risk loci for RLS has not been studied. Our aim was to evaluate whether carriers of specific RLS risk alleles have higher comorbidity burden than noncarriers. Methods: The Dortmund Health Study (DHS) and the Study of Health in Pomerania (SHIP) are two independent cohort studies in Germany based on agestratified, random samples drawn from the respective population registers. DHS included 1,312 subjects and SHIP included 4,308 subjects. RLS status was assessed according to the RLS standard minimal criteria. A comorbidity index was calculated by summing the scores of the following conditions: diabetes, hypertension, myocardial infarction, obesity, stroke, cancer, renal disease, anemia, depression, thyroid disease, and migraine. Thirteen single nucleotide polymorphisms (SNP) previously associated with elevated risk of RLS were genotyped. Analyses were carried out on the pooled sample of the two studies. Results: The mean age was 50.4 ± 15.9 y, and the proportion of women was 51.4%. The mean number of comorbid conditions was 1.5 ± 1.3. In multivariable regression, the mean number of comorbidities was not significantly different between carriers of any of the RLS risk alleles and noncarriers either in the total pooled sample or in those having RLS symptoms. Conclusions: Based on these results it is unlikely that known genetic risk factors for RLS would lead to increased multimorbidity.

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