Lack of a specific effect of corticotropin-releasing hormone (CRH) on plasma levels of 13,14-dihydro-15-keto-prostaglandin E2 in normal subjects

S. Zacharieva, I. Muchá, M. Wippermann, S. Sheitanova, K. Andonova

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The responses of plasma adrenocorticotrophic hormone (corticotrophin, ACTH), cortisol and 13,14-dihydro-15-keto-prostaglandin E2 (PGE2-M), a stable metabolite of prostaglandin E2 (PGE2) to i.v. injection of corticotrophin-releasing hormone (CRH) were studied in eight healthy subjects before and after a dexamethasone suppression test. We demonstrated a slight increase in PGE2-M after CRH injection in a dose that markedly augmented ACTH and cortisol levels. CRH did not produce any significant changes in ACTH, cortisol or PGE2-M after dexamethasone treatment. The results did not confirm a specific effect of CRH on PGE2 production.

Original languageEnglish
Pages (from-to)55-57
Number of pages3
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume52
Issue number1
DOIs
Publication statusPublished - 1995

Fingerprint

Corticotropin-Releasing Hormone
Dinoprostone
Adrenocorticotropic Hormone
Plasmas
Hydrocortisone
Dexamethasone
Injections
Metabolites
Healthy Volunteers
15-ketoprostaglandin E2
7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Lack of a specific effect of corticotropin-releasing hormone (CRH) on plasma levels of 13,14-dihydro-15-keto-prostaglandin E2 in normal subjects. / Zacharieva, S.; Muchá, I.; Wippermann, M.; Sheitanova, S.; Andonova, K.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 52, No. 1, 1995, p. 55-57.

Research output: Contribution to journalArticle

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AU - Andonova, K.

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