Neuroendokrin tüdõtumorok laboratóriumi kivizsgálása

Translated title of the contribution: Laboratory diagnostics of lung neuroendocrine tumors

Research output: Contribution to journalArticle

Abstract

Perhaps innovations in protein and peptide analysis utilizing immunochemistry methodology have been the most demarcating in the field of routine laboratory diagnostics in the past few decades. Presently, the state of art immunochemistry (e.g., immunofluorimetry, electrochemiluminescence) and separation techniques (e.g., high pressure liquid chromatography) facilitate achievement of detection limits well below the nmol/L range. These techniques have allowed reproducible and high throughput analysis with a short turnaround time of tumor markers, among others, in the routine diagnostic laboratory setting. Tumor marker determination is an integral part of the diagnostic work-up of tumors, and is indispensable in therapeutic monitoring and clinical decision-making. This article presents the utility of tumor markers in the diagnostics of lung neuroendocrine tumors (NET). Furthermore, since the majority of the tests used in lung NET diagnostics are infrequently requested, quite a few practical issues are also discussed. The generally applicable rule pertaining to tumor markers is also valid for NET diagnostics, i.e., improved sensitivity and specificity is widely achieved with a combination of tumor markers, as such, promoting diagnosis, efficient therapeutic monitoring and defining the prognosis.

Original languageHungarian
Pages (from-to)108-112
Number of pages5
JournalMagyar onkologia
Volume62
Issue number2
Publication statusPublished - Jul 20 2018

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Neuroendocrine Tumors
Tumor Biomarkers
Lung
Immunochemistry
Limit of Detection
High Pressure Liquid Chromatography
Sensitivity and Specificity
Peptides
Therapeutics
Neoplasms
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Neuroendokrin tüdõtumorok laboratóriumi kivizsgálása. / Kappelmayer, J.; Bhattoa, H.

In: Magyar onkologia, Vol. 62, No. 2, 20.07.2018, p. 108-112.

Research output: Contribution to journalArticle

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