Label-free optical biosensors for monitoring cellular processes and cytotoxic agents at interfaces using guided modes and advanced phase-contrast imaging techniques

Inna Székács, Robert Horvath, András Székács

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Novel optical biosensors in direct interaction with living cells open new avenues in the detection of given cell types, including pathogenic microorganisms, and in the measurement of cytotoxicity of given xenobiotics, such as biothreat agents, on suitably selected cell types or lines. Evanescent optical field based biosensors emerging for such applications are reviewed, covering surface plasmon and waveguide based formats, imaging setup, employing optical waveguides, and digital holographic microscopy. Commercial technologies, along with main pathogenic microorganisms (Bacillus anthracis, Escherichia coli, Listeria monocytogenes, Campylobacter jejuni, etc.) as analytes and cell lines (native tissue and tumor cells) as cytotoxicity effect subjects are highlighted.

Original languageEnglish
Title of host publicationAdvanced Sciences and Technologies for Security Applications
PublisherSpringer
Pages443-468
Number of pages26
DOIs
Publication statusPublished - Jan 1 2016

Publication series

NameAdvanced Sciences and Technologies for Security Applications
ISSN (Print)1613-5113
ISSN (Electronic)2363-9466

Keywords

  • Cell biosensor
  • Cytotoxicity
  • Digital holographic microscopy
  • Evanescent field
  • Optical waveguide
  • Pathogenic microorganisms

ASJC Scopus subject areas

  • Safety, Risk, Reliability and Quality
  • Safety Research
  • Political Science and International Relations
  • Computer Science Applications
  • Computer Networks and Communications
  • Health, Toxicology and Mutagenesis

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  • Cite this

    Székács, I., Horvath, R., & Székács, A. (2016). Label-free optical biosensors for monitoring cellular processes and cytotoxic agents at interfaces using guided modes and advanced phase-contrast imaging techniques. In Advanced Sciences and Technologies for Security Applications (pp. 443-468). (Advanced Sciences and Technologies for Security Applications). Springer. https://doi.org/10.1007/978-3-319-28926-7_21