L-Dopa metabolism in genetically hypertensive mice

Effect of pargyline

N. T. Buu, J. Duhaime, K. Rácz, O. Kuchel, G. Schlager

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This study on the role of the sympathetic nervous system in the development of hypertension involves the measurement of dopamine and norepinephrine accumulation in various tissues of the hypertensive and random-bred normotensive strains of mice at basal levels, and following a pargyline-L-dopa treatment. Under such a treatment, designed to suppress the homeostatic action of monoamine oxidase and to better expose the relationship between dopamine and norepinephrine, the brain and heart of the hypertensive mice accumulated more dopamine than the normotensive mice. There was a significantly lower norepinephrine accumulation in the heart of the hypertensive mice in spite of comparable dopamine-β-hydroxylase activity in this tissue between the two strains of mice. Under the pargyline-L-dopa treatment, the brain and heart of the older mice in both hypertensive and normotensive strains accumulated significantly (p

Original languageEnglish
Pages (from-to)2390-2395
Number of pages6
JournalCanadian Journal of Physiology and Pharmacology
Volume65
Issue number12
Publication statusPublished - 1987

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Pargyline
Levodopa
Dopamine
Norepinephrine
Sympathetic Nervous System
Monoamine Oxidase
Brain
Mixed Function Oxygenases
Hypertension

ASJC Scopus subject areas

  • Physiology
  • Pharmacology

Cite this

L-Dopa metabolism in genetically hypertensive mice : Effect of pargyline. / Buu, N. T.; Duhaime, J.; Rácz, K.; Kuchel, O.; Schlager, G.

In: Canadian Journal of Physiology and Pharmacology, Vol. 65, No. 12, 1987, p. 2390-2395.

Research output: Contribution to journalArticle

Buu, NT, Duhaime, J, Rácz, K, Kuchel, O & Schlager, G 1987, 'L-Dopa metabolism in genetically hypertensive mice: Effect of pargyline', Canadian Journal of Physiology and Pharmacology, vol. 65, no. 12, pp. 2390-2395.
Buu, N. T. ; Duhaime, J. ; Rácz, K. ; Kuchel, O. ; Schlager, G. / L-Dopa metabolism in genetically hypertensive mice : Effect of pargyline. In: Canadian Journal of Physiology and Pharmacology. 1987 ; Vol. 65, No. 12. pp. 2390-2395.
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