L-deprenyl plus l-phenylalanine in the treatment of depression

W. Birkmayer, P. Riederer, W. Linauer, J. Knoll

Research output: Contribution to journalArticle

35 Citations (Scopus)


The antidepressive efficacy of l-deprenyl (5-10 mg daily) plus l-phenylalanine (250 mg/day) has been evaluated in 155 unipolar depressed patients. Both oral and intravenous administration showed beneficial effects in 90% of outpatients and 80.5% of inpatients. It is concluded that this combined treatment has a potent antidepressive action based on the accumulation of l-phenylethylamine in the brain.

Original languageEnglish
Pages (from-to)81-87
Number of pages7
JournalJournal of neural transmission
Issue number1
Publication statusPublished - Mar 1 1984


  • Depression syndrome
  • antidepressants
  • deprenyl
  • phenylalanine

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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