Observations carried out in 74 children with acute lymphoid leukaemia revealed that the effect of L-asparaginase, similarly to that of other cytostatic drugs, is not entirely selective. If given with certain precautions, the drug can still be included in the initial induction protocol for the treatment of acute lymphoid leukaemia and generalized lymphosarcoma and will ensure favourable results. Administration of 4 injections during a period of 8 days induced complications in 7.9%. In order to avoid a dangerous rise in the blood ammonia level, L-asparaginase treatment should be started a few days after the initiation of therapy with other cytostatic drugs. In this way the number of severe complications is reduced. The repeated use of L-asparaginase is not recommended even in the case of relapse, as this mode of application can lead to allergic reactions or even to anaphylactic shock.
|Number of pages||7|
|Publication status||Published - Dec 1 1976|
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