L-Arginine improves endothelial and myocardial function after brain death

G. Szabó, P. Soós, Ulrike Heger, Susanne Mandera, Volker Buhmann, Susanne Bährle, Brigitte Kohl, Siegfried Hagl

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

BACKGROUND. Recently, we showed that brain death (BD) leads to a severe impairment of endothelial function. METHODS. To test the hypothesis, that nitric oxide supply improves endothelial function, we infused L-arginine (40 mg/kg) in 6 dogs after BD induction (subdural balloon). Six vehicle-treated BD animals served as controls. Coronary blood flow (CBF), preload recruitable stroke work (PRSW), and plasma L-arginine and nitrite/nitrate levels were measured before and 6 hr after BD induction. In addition, endothelium-dependent vasodilatation after intracoronary application of acetylcholine (ACH) and endothelium- independent vasodilation after sodium nitroprusside (SNP) were assessed. RESULTS. Six hours after BD, CBF decreased significantly in the control group (38.2±3.5 vs. 26.8±3.1 ml/min, P

Original languageEnglish
Pages (from-to)108-112
Number of pages5
JournalTransplantation
Volume82
Issue number1
DOIs
Publication statusPublished - Jul 2006

Fingerprint

Brain Death
Arginine
Vasodilation
Endothelium
Nitroprusside
Nitrites
Nitrates
Acetylcholine
Nitric Oxide
Stroke
Dogs
Control Groups

Keywords

  • Brain death
  • Contractility
  • Endothelium
  • Nitric oxide
  • Vascular function

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

L-Arginine improves endothelial and myocardial function after brain death. / Szabó, G.; Soós, P.; Heger, Ulrike; Mandera, Susanne; Buhmann, Volker; Bährle, Susanne; Kohl, Brigitte; Hagl, Siegfried.

In: Transplantation, Vol. 82, No. 1, 07.2006, p. 108-112.

Research output: Contribution to journalArticle

Szabó, G, Soós, P, Heger, U, Mandera, S, Buhmann, V, Bährle, S, Kohl, B & Hagl, S 2006, 'L-Arginine improves endothelial and myocardial function after brain death', Transplantation, vol. 82, no. 1, pp. 108-112. https://doi.org/10.1097/01.tp.0000225778.49388.f5
Szabó, G. ; Soós, P. ; Heger, Ulrike ; Mandera, Susanne ; Buhmann, Volker ; Bährle, Susanne ; Kohl, Brigitte ; Hagl, Siegfried. / L-Arginine improves endothelial and myocardial function after brain death. In: Transplantation. 2006 ; Vol. 82, No. 1. pp. 108-112.
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