L-Arginine and S-nitrosoglutathione reduce embolization in humans

Z. Káposzta, Paul A. Baskerville, David Madge, Simon Fraser, John F. Martin, Hugh S. Markus

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Background - L-Arginine reduces platelet aggregation and adhesion in ex vivo studies, but there is no evidence as yet that it has a therapeutic effect on clinical end points. Doppler ultrasound can detect cerebral emboli noninvasively. Such embolic signals are common after carotid endarterectomy, and their frequency predicts risk of stroke recurrence. We used this situation to determine the antiplatelet efficacy of L-arginine and S-nitrosoglutathione (GSNO), a physiological nitric oxide donor with possible platelet specificity. Methods and Results - Patients undergoing carotid endarterectomy were randomized in a double-blind manner between L-arginine (n= 14), GSNO (n= 14), or placebo (n= 14) administered intravenously for 90 minutes, starting 30 minutes after skin closure. All patients were pretreated with aspirin and given heparin during surgery. Transcranial Doppler recordings were made from the ipsilateral middle cerebral artery for 4 hours after surgery, beginning 30 minutes after skin closure, and also at 6 and 24 hours. There were highly significant reductions in the number of Doppler embolic signals in the L-arginine and GSNO groups; first 4 hours, median (range) number of embolic signals, placebo 44.7 (6 to 778), L-arginine 9.5 (0 to 225), and GSNO 0.8 (0 to 8), both P

Original languageEnglish
Pages (from-to)2371-2375
Number of pages5
JournalCirculation
Volume103
Issue number19
Publication statusPublished - May 15 2001

Fingerprint

S-Nitrosoglutathione
Arginine
Carotid Endarterectomy
Placebos
Intracranial Embolism
Doppler Ultrasonography
Skin
Nitric Oxide Donors
Middle Cerebral Artery
Therapeutic Uses
Platelet Aggregation
Aspirin
Heparin
Blood Platelets
Stroke
Recurrence

Keywords

  • Carotid arteries
  • Drugs
  • Inhibitors
  • Platelets
  • Ultrasonics

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Káposzta, Z., Baskerville, P. A., Madge, D., Fraser, S., Martin, J. F., & Markus, H. S. (2001). L-Arginine and S-nitrosoglutathione reduce embolization in humans. Circulation, 103(19), 2371-2375.

L-Arginine and S-nitrosoglutathione reduce embolization in humans. / Káposzta, Z.; Baskerville, Paul A.; Madge, David; Fraser, Simon; Martin, John F.; Markus, Hugh S.

In: Circulation, Vol. 103, No. 19, 15.05.2001, p. 2371-2375.

Research output: Contribution to journalArticle

Káposzta, Z, Baskerville, PA, Madge, D, Fraser, S, Martin, JF & Markus, HS 2001, 'L-Arginine and S-nitrosoglutathione reduce embolization in humans', Circulation, vol. 103, no. 19, pp. 2371-2375.
Káposzta Z, Baskerville PA, Madge D, Fraser S, Martin JF, Markus HS. L-Arginine and S-nitrosoglutathione reduce embolization in humans. Circulation. 2001 May 15;103(19):2371-2375.
Káposzta, Z. ; Baskerville, Paul A. ; Madge, David ; Fraser, Simon ; Martin, John F. ; Markus, Hugh S. / L-Arginine and S-nitrosoglutathione reduce embolization in humans. In: Circulation. 2001 ; Vol. 103, No. 19. pp. 2371-2375.
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