Kynurenines, redox disturbances and neurodegeneration in multiple sclerosis

C. Rajda, J. Bergquist, L. Vécsei

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Citations (Scopus)

Abstract

Multiple sclerosis (MS) is a chronic, demyelinating disease of unknown origin. Sophisticated analytical methods have made it possible to measure small biologically active molecules at low endogenous levels, and understand their role in the network of other biologically active compounds actively involved in inflammatory and neurodegenerative processes. Evidence is accumulating as concerns the disturbances of the kynurenine pathway and redox changes in MS. A new promising metabolite of the kynurenine pathway seems to beneficially influence experimental allergic encephalomyelitis. More clinical evidence is needed to prove the role of kynurenic acid analogues and/or enzyme inhibitors as potential medications in MS in the future. Various compounds have been shown to be important in the pathophysiological processes of the disease and are targets for pharmaceutical intervention.

Original languageEnglish
Title of host publicationNeuropsychiatric Disorders An Integrative Approach
EditorsManfred Gerlach, Jurgen Deckert, Kay Double, Eleni Koutsilieri
Pages323-329
Number of pages7
Edition72
DOIs
Publication statusPublished - Dec 1 2007

Publication series

NameJournal of Neural Transmission, Supplementa
Number72
ISSN (Print)0303-6995

Keywords

  • Antioxidants
  • experimental allergic encephalomyelitis
  • kynurenic acid
  • kynurenine
  • multiple sclerosis
  • redox disturbance

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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  • Cite this

    Rajda, C., Bergquist, J., & Vécsei, L. (2007). Kynurenines, redox disturbances and neurodegeneration in multiple sclerosis. In M. Gerlach, J. Deckert, K. Double, & E. Koutsilieri (Eds.), Neuropsychiatric Disorders An Integrative Approach (72 ed., pp. 323-329). (Journal of Neural Transmission, Supplementa; No. 72). https://doi.org/10.1007/978-3-211-73574-9-40