Kynurenines in the CNS: Recent advances and new questions

L. Vécsei, Levente Szalárdy, F. Fülöp, J. Toldi

Research output: Contribution to journalArticle

260 Citations (Scopus)

Abstract

Various pathologies of the central nervous system (CNS) are accompanied by alterations in tryptophan metabolism. The main metabolic route of tryptophan degradation is the kynurenine pathway; its metabolites are responsible for a broad spectrum of effects, including the endogenousRegulation of neuronal excitability and the initiation of immune tolerance. This Review highlights the involvement of the kynurenine system in the pathology of neurodegenerative disorders, pain syndromes and autoimmune diseases through a detailed discussion of its potential implications in Huntington's disease, migraine and multiple sclerosis. The most effective preclinical drug candidates are discussed and attention is paid to currently under-investigated roles of the kynurenine pathway in the CNS, where modulation of kynurenine metabolism might be of therapeutic value.

Original languageEnglish
Pages (from-to)64-82
Number of pages19
JournalNature Reviews Drug Discovery
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 2013

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Kynurenine
Central Nervous System
Tryptophan
Pathology
Immune Tolerance
Huntington Disease
Migraine Disorders
Neurodegenerative Diseases
Autoimmune Diseases
Multiple Sclerosis
Pain
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

Kynurenines in the CNS : Recent advances and new questions. / Vécsei, L.; Szalárdy, Levente; Fülöp, F.; Toldi, J.

In: Nature Reviews Drug Discovery, Vol. 12, No. 1, 01.2013, p. 64-82.

Research output: Contribution to journalArticle

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